Document Detail

Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action.
MedLine Citation:
PMID:  3839709     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y (NPY), which exists in very high concentrations in the brain, has been shown to elicit a powerful feeding response and a small drinking response in satiated rats. In order to delineate the brain sites sensitive to these effects, NPY was injected through chronic guide cannulas into seven different brain regions, and the food and water intake of satiated rats was measured one hr postinjection. Injection of NPY (78 pmoles) into hypothalamic areas, namely the paraventricular nucleus (PVN), ventromedial hypothalamus (VMH), and lateral hypothalamus (LH), elicited a strong feeding response; in contrast, injections into extra-hypothalamic areas, namely the amygdala, thalamus, and periaqueductal gray, were completely ineffective. Administration of NPY into the PVN and VMH also elicited a small drinking response; however, all other areas, including the LH, were insensitive to this effect. The findings that NPY was effective in the hypothalamus, as opposed to sites anterior, posterior, lateral or dorsal to this structure, suggest a hypothalamic site(s) of action for this neuropeptide.
B G Stanley; A S Chin; S F Leibowitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  14     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-10-22     Completed Date:  1985-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-4     Citation Subset:  IM    
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MeSH Terms
Drinking Behavior / drug effects*
Feeding Behavior / drug effects*
Hypothalamus / drug effects*
Injections, Intraventricular
Nerve Tissue Proteins / administration & dosage*,  pharmacology
Neuropeptide Y
Paraventricular Hypothalamic Nucleus / drug effects
Rats, Inbred Strains
Time Factors
Ventromedial Hypothalamic Nucleus / drug effects
Grant Support
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptide Y

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