Document Detail


Feeding and communication impairments in infants with central grey matter lesions following perinatal hypoxic-ischaemic injury.
MedLine Citation:
PMID:  22658307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Basal ganglia and thalamic (BGT) injury is common after acute perinatal hypoxia-ischaemia. Cerebral palsy is the most obvious consequence of BGT injury affecting 70-75% of survivors and is predictable from neonatal magnetic resonance imaging (MRI). However there is no equivalent predictive data for other specific outcomes. Feeding and communication impairments are also common in children following hypoxic-ischaemic encephalopathy (HIE) and BGT injury.
AIMS: To describe, in infants with HIE and BGT injury, the prevalence of feeding and communication impairments; and to evaluate the accuracy of early MRI for predicting these outcomes.
METHODS: 175 term infants with HIE and BGT injury were studied. Brain lesions were classified by site and severity from the MRI scans. Motor, feeding and communication impairments were documented at 2 years.
RESULTS: Feeding and communication impairments occurred in 65% and 82% of 126 survivors respectively and related strongly to the severity of motor impairment. Forty-one children had a gastrostomy or long-term nasogastric tube. Injury severity in all brain regions was significantly associated with feeding and communication impairment on univariate analysis. On logistic regression analysis BGT (OR 10.9) and mesencephalic lesions (OR 3.7) were independently associated with feeding impairment; BGT (OR 10.5) and pontine lesions (OR 3.8) were associated with gastrostomy; the severity of BGT lesions (OR 20.1) was related to the severity of communication impairment.
CONCLUSIONS: Feeding and communication impairment are very common in children with BGT and brainstem injury of neonatal origin and can be well predicted from early MRI scans.
Authors:
Miriam Martinez-Biarge; Jesus Diez-Sebastian; Courtney J Wusthoff; Stacey Lawrence; Annie Aloysius; Mary A Rutherford; Frances M Cowan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-31
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  16     ISSN:  1532-2130     ISO Abbreviation:  Eur. J. Paediatr. Neurol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  688-96     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Basal Ganglia Diseases / pathology,  psychology
Brain / pathology*
Brain Stem / pathology
Cerebral Cortex / pathology
Child, Preschool
Communication Disorders / etiology*,  psychology
Deglutition Disorders / etiology
Enteral Nutrition
Feeding and Eating Disorders of Childhood / etiology*,  psychology
Female
Follow-Up Studies
Humans
Hypoxia-Ischemia, Brain / pathology*,  psychology*
Infant
Infant, Newborn
Magnetic Resonance Imaging
Male
Movement / physiology
Predictive Value of Tests
Thalamus / pathology
Treatment Outcome
Grant Support
ID/Acronym/Agency:
MR/K006355/1//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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