Document Detail


Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves.
MedLine Citation:
PMID:  11285335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of amounts of colostrum consumed on intestinal morphology and proliferation and digestive enzyme activities in neonatal calves. Group GrCmax calves were fed colostrum from the first milking undiluted on d 1-3 and diluted with 25, 50, 75 and 75 parts of a milk replacer on d 4-7. Group GrC1-3 calves were fed colostrum from milkings 1-6 up to d 3 and then a milk replacer up to d 7. Group GrF1-3 calves were fed a milk-based formula (containing only traces of growth factors and hormones) up to d 3 and then a milk replacer up to d 7. Calves were killed on d 8. Differences in feeding affected villus sizes and villus height/crypt depth ratios in the duodenum (GrCmax > GrC1-3), villus areas and villus height/crypt depth ratios in the jejunum (GrC1-3 > GrF1-3) and crypt depths in the colon (GrF1-3 > GrC1-3). Furthermore, different feeding protocols affected the proliferation rates of epithelial cells in the duodenum (GrC1-3 > GrCmax; GrC1-3 > GrF1-3) and the jejunum (GrF1-3 > GrC1-3; based on Ki-67 labeling). Lipase activities in the pancreas were influenced by colostrum feeding (GrC(max) > GrC(1-3)). Colostrum intake differentially affected intestinal epithelial surface and proliferation and enzyme activities. Feeding high amounts of first colostrum seemed to enhance the survival of mature mucosal epithelial cells in selected parts of the small intestine, whereas the lack of colostrum seemed to decrease epithelial growth.
Authors:
U Blättler; H M Hammon; C Morel; C Philipona; A Rauprich; V Romé; I Le Huërou-Luron; P Guilloteau; J W Blum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-04     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1256-63     Citation Subset:  IM    
Affiliation:
Division of Nutritional Pathology, Faculty of Veterinary Medicine, CH-3012 Berne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / anatomy & histology,  physiology*
Body Weight
Cattle
Cell Division / physiology
Colon / anatomy & histology,  cytology
Colostrum* / chemistry
DNA / metabolism
Diet*
Digestion / physiology*
Enzymes / metabolism*
Health Status
Intestinal Mucosa / cytology
Intestine, Small / anatomy & histology,  cytology
Intestines / anatomy & histology,  cytology*,  metabolism
Jejunum / enzymology
Male
Pancreas / enzymology,  metabolism
Proteins / metabolism
RNA / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Enzymes; 0/Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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