Document Detail


Feeding behaviors and ORXR-β-GABA A R subunit interactions in Carassius auratus.
MedLine Citation:
PMID:  22001787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Orexins are one of the most potent orexigenic factors in fish that through their interaction with the GABA(A) receptor system assures the successful execution of feeding, motor and sleep-wake activities. In the present study, the effects of ORX-A (10ng/g BW) very greatly enhanced (p<0.001) the time spent in feeding behaviors while at the same time moderately increased (p<0.05) food intake of the goldfish. It is worthy to note that the great variations of time spent in feeding behaviors induced by β GABA(A)R agonist (muscimol, MUS) and antagonist (bicuculline, BIC) did not result to be correlated to any significant variations of food intake. It was, however, a T-maze study allowing us to establish that learning and mnemonic events very likely also operated in an ORX-A+GABA(A)R-dependent fashion in our fish model. Indeed, animals conditioned by red/blue lights greatly reduced latency time in the presence of ORX-A while neither MUS nor BIC alone modified such a parameter, with the exception of ORX-A+MUS being responsible for a moderate decrease of latency time with respect to conditioned fish treated with a saline solution. Conversely, ORX-A+MUS/BIC seemed to interfere with ORX-A actions as shown by their very great increase in latency time. Moreover, T-maze results appeared to be strengthened by evident ORXR transcriptional variations especially by the very great mRNA densities detected in some telencephalic regions of animals treated with ORX-A. Of all telencephalic regions Dl, considered homologous to the mammalian hippocampus, proved to be a major target for ORX-A effects. Overall, these data suggest that it is mainly the ORXergic system that promotes feeding behaviors via reward pathways in teleost fish as in mammals. Surprisingly, β GABA(A)R drugs did not modify such behaviors when given alone while the inhibitory effect on cognitive/reward processes was evoked when given together with ORX-A, suggesting that more than β subunits other GABA(A)R subunits could be promoting mnemonically guided motor behaviors.
Authors:
Rosa Maria Facciolo; Michele Crudo; Merylin Zizza; Giuseppina Giusi; Marcello Canonaco
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Publication Detail:
Type:  Journal Article     Date:  2011-10-05
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  33     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-05-14     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  641-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Drug Interactions
Eating / drug effects,  physiology
Feeding Behavior / drug effects,  physiology*
GABA-A Receptor Agonists / pharmacology
GABA-A Receptor Antagonists / pharmacology
Goldfish / metabolism,  physiology*
In Situ Hybridization
Intracellular Signaling Peptides and Proteins / pharmacology
Maze Learning / drug effects,  physiology
Motor Activity / drug effects,  physiology*
Neuropeptides / pharmacology
Orexin Receptors
Receptors, G-Protein-Coupled / genetics,  metabolism*
Receptors, GABA-A / genetics,  metabolism*
Receptors, Neuropeptide / genetics,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Reward
Time Factors
Chemical
Reg. No./Substance:
0/GABA-A Receptor Agonists; 0/GABA-A Receptor Antagonists; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Orexin Receptors; 0/Receptors, G-Protein-Coupled; 0/Receptors, GABA-A; 0/Receptors, Neuropeptide; 0/orexins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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