Document Detail

Feeding behavior and ambulatory activity in rats with D-galactosamine-induced hepatic failure.
MedLine Citation:
PMID:  1352048     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to investigate changes in feeding behavior and ambulatory activity, in rats with D-galactosamine (D-GAL)-induced hepatic failure. D-GAL was administered (1000 mg/kg) IP at 1800, just before the dark phase. The first significant decrease of ambulatory activity in rats with hepatic failure was observed between 0000 and 0300 h. A significant increase in drinking behavior was observed between 1800 and 2100 h, and a significant decrease was observed between 2100 and 0300 h. A significant decrease in food intake occurred between 1800 and 2400 h. Thereafter, there was no difference in food intake. In conclusion, we demonstrated significant changes in ambulatory activity, drinking behavior and food intake produced by D-GAL. A wide variation in systems, including monoamine turnover, and amino acid disturbance could be expected in these animals, and such changes might also have contributed to the results observed.
Y Shimomura; S Saito; T Nagamine; H Shimizu; M Takahashi; Y Uehara; N Sato; M Negishi; S Yamada; I Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  51     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-29     Completed Date:  1992-07-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1029-33     Citation Subset:  IM    
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
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MeSH Terms
Amino Acids, Branched-Chain / blood
Circadian Rhythm / drug effects,  physiology
Consummatory Behavior / drug effects,  physiology
Corpus Striatum / drug effects,  physiopathology
Feeding Behavior / drug effects*,  physiology
Galactosamine / pharmacology*
Hepatic Encephalopathy / chemically induced,  physiopathology*
Motor Activity / drug effects*,  physiology
Neurotransmitter Agents / metabolism
Phenylalanine / blood
Rats, Inbred Strains
Tryptophan / blood
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Neurotransmitter Agents; 63-91-2/Phenylalanine; 73-22-3/Tryptophan; 7535-00-4/Galactosamine

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