Document Detail


Feeding behavior of Aplysia: a model system for comparing cellular mechanisms of classical and operant conditioning.
MedLine Citation:
PMID:  17142299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Feeding behavior of Aplysia provides an excellent model system for analyzing and comparing mechanisms underlying appetitive classical conditioning and reward operant conditioning. Behavioral protocols have been developed for both forms of associative learning, both of which increase the occurrence of biting following training. Because the neural circuitry that mediates the behavior is well characterized and amenable to detailed cellular analyses, substantial progress has been made toward a comparative analysis of the cellular mechanisms underlying these two forms of associative learning. Both forms of associative learning use the same reinforcement pathway (the esophageal nerve, En) and the same reinforcement transmitter (dopamine, DA). In addition, at least one cellular locus of plasticity (cell B51) is modified by both forms of associative learning. However, the two forms of associative learning have opposite effects on B51. Classical conditioning decreases the excitability of B51, whereas operant conditioning increases the excitability of B51. Thus, the approach of using two forms of associative learning to modify a single behavior, which is mediated by an analytically tractable neural circuit, is revealing similarities and differences in the mechanisms that underlie classical and operant conditioning.
Authors:
Douglas A Baxter; John H Byrne
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Learning & memory (Cold Spring Harbor, N.Y.)     Volume:  13     ISSN:  1072-0502     ISO Abbreviation:  Learn. Mem.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-01-25     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9435678     Medline TA:  Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  669-80     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Houston, Texas 77030, USA. Douglas.Baxter@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Aplysia / physiology*
Appetitive Behavior / physiology
Association Learning / physiology*
Conditioning, Classical / physiology*
Conditioning, Operant / physiology*
Feeding Behavior / physiology*
Models, Animal
Neural Pathways / cytology,  physiology
Neurons / physiology*
Reinforcement (Psychology)
Grant Support
ID/Acronym/Agency:
R01MH 58321/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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