| Feeding Rats Dietary Resistant Starch Reduces both the Binding of ChREBP and the Acetylation of Histones on the Thrsp Gene in the Jejunum. | |
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MedLine Citation:
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PMID: 21244091 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have previously reported that the thyroid hormone-responsive spot 14 protein (Thrsp) gene is expressed in rat jejunum. In this study, we found that jejunal mRNA and protein expressions of Thrsp were markedly reduced in rats fed a diet containing a high amount of resistant starch (RS), which is an indigestible starch, for 7 days, compared with those fed a regular starch diet. Furthermore, we found that the binding of carbohydrate response element binding protein (ChREBP), which is a key transcription factor for the Thrsp gene, and the acetylation of histones H3 and H4, which is one of the histone modifications for transactivation, on the Thrsp gene were reduced by feeding the RS diet. These results suggest that the reduction of jejunal Thrsp gene expression by feeding a diet rich in less-digestible starch is associated with decreases in the binding of ChREBP and the acetylation of histones on the gene. |
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Authors:
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Masaya Shimada; Kazuki Mochizuki; Toshinao Goda |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-18 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nutrition, Faculty of Health Sciences, Chiba Prefectural University of Health Sciences, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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