Document Detail


Feedforward inhibition of the rat entorhinal cortex and subicular complex.
MedLine Citation:
PMID:  3249220     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used in vivo intracellular recording techniques in order to provide evidence about the source of postsynaptic inhibition in the rat entorhinal cortex and subicular complex. Several different structures in the basal forebrain and hippocampus were electrically stimulated in order to activate inhibition by different pathways. This allowed a test of 2 different neuronal circuit models: feedback inhibition, in which recurrent collaterals from principal cell axons excite a local population of inhibitory neurons, and feedforward inhibition, in which excitatory afferents activate the inhibitory neurons. In both models, inhibitory cell axons branch and contribute to the inhibition of a population of principal cells. In the feedback model, a good correlation between antidromic and inhibitory response latencies is predicted. The feedforward model predicts independent antidromic and inhibitory response latencies. In one particular model of feedforward inhibition, afferents excite both local inhibitory cells and principal cells. This model predicts a high correlation between principal cell EPSP and IPSP latencies. The results showed no consistent relationship between the presence of antidromic action potentials and the presence of inhibition in response to stimulation of different sites. In addition, there was no correlation between antidromic and inhibitory response latencies. These results provide no clear support for the feedback model of inhibition. By contrast, there was a highly significant correlation between the latency of principal cell EPSPs and IPSPs, in support of a feedforward model of inhibition. Response latencies of candidate inhibitory neurons were also consistent with the feedforward model. The results provide evidence that an excitatory relay function of the entorhinal cortex and subicular complex is modified temporally by local, extrinsically activated inhibitory circuits.
Authors:
D M Finch; A M Tan; M Isokawa-Akesson
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  8     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-06-29     Completed Date:  1989-06-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2213-26     Citation Subset:  IM    
Affiliation:
Department of Neurology, Reed Neurological Research Center, University of California, Los Angeles 90024.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation
Electrophysiology
Feedback
Hippocampus / cytology,  physiology*
Limbic System / cytology,  physiology*
Neural Inhibition*
Neurons / physiology
Piperidines / diagnostic use*,  metabolism,  pharmacology
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
NS 16721/NS/NINDS NIH HHS; NS 23074/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Piperidines; 75259-67-5/5-hydroxyindalpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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