Document Detail

Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder.
MedLine Citation:
PMID:  17681544     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Given growing evidence that respiratory dysregulation is a central feature of panic disorder (PD) interventions for panic that specifically target respiratory functions could prove clinically useful and scientifically informative. We tested the effectiveness of a new, brief, capnometry-assisted breathing therapy (BRT) on clinical and respiratory measures in PD.
METHODS: Thirty-seven participants with PD with or without agoraphobia were randomly assigned to BRT or to a delayed-treatment control group. Clinical status, respiration rate, and end-tidal pCO(2) were assessed at baseline, post-treatment, 2-month and 12-month follow-up. Respiratory measures were also assessed during homework exercises using a portable capnometer as a feedback device.
RESULTS: Significant improvements (in PD severity, agoraphobic avoidance, anxiety sensitivity, disability, and respiratory measures) were seen in treated, but not untreated patients, with moderate to large effect sizes. Improvements were maintained at follow-up. Treatment compliance was high for session attendance and homework exercises; dropouts were few.
CONCLUSIONS: The data provide preliminary evidence that raising end-tidal pCO(2) by means of capnometry feedback is therapeutically beneficial for panic patients. Replication and extension will be needed to verify this new treatment's efficacy and determine its mechanisms.
Alicia E Meuret; Frank H Wilhelm; Thomas Ritz; Walton T Roth
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-08-03
Journal Detail:
Title:  Journal of psychiatric research     Volume:  42     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-08-07     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  560-8     Citation Subset:  IM    
Department of Psychology, Southern Methodist University, 6424 Hilltop Lane, Dallas, TX 75205, United States.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous
Breathing Exercises*
Carbon Dioxide / metabolism*
Disability Evaluation
Hyperventilation / diagnosis,  epidemiology
Middle Aged
Panic Disorder / epidemiology,  metabolism*,  therapy*
Tidal Volume / physiology*
Waiting Lists
Grant Support
R01 MH056094-04/MH/NIMH NIH HHS
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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