| Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder. | |
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MedLine Citation:
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PMID: 17681544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Given growing evidence that respiratory dysregulation is a central feature of panic disorder (PD) interventions for panic that specifically target respiratory functions could prove clinically useful and scientifically informative. We tested the effectiveness of a new, brief, capnometry-assisted breathing therapy (BRT) on clinical and respiratory measures in PD. METHODS: Thirty-seven participants with PD with or without agoraphobia were randomly assigned to BRT or to a delayed-treatment control group. Clinical status, respiration rate, and end-tidal pCO(2) were assessed at baseline, post-treatment, 2-month and 12-month follow-up. Respiratory measures were also assessed during homework exercises using a portable capnometer as a feedback device. RESULTS: Significant improvements (in PD severity, agoraphobic avoidance, anxiety sensitivity, disability, and respiratory measures) were seen in treated, but not untreated patients, with moderate to large effect sizes. Improvements were maintained at follow-up. Treatment compliance was high for session attendance and homework exercises; dropouts were few. CONCLUSIONS: The data provide preliminary evidence that raising end-tidal pCO(2) by means of capnometry feedback is therapeutically beneficial for panic patients. Replication and extension will be needed to verify this new treatment's efficacy and determine its mechanisms. |
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Authors:
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Alicia E Meuret; Frank H Wilhelm; Thomas Ritz; Walton T Roth |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-08-03 |
Journal Detail:
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Title: Journal of psychiatric research Volume: 42 ISSN: 0022-3956 ISO Abbreviation: J Psychiatr Res Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-08-07 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: England |
Other Details:
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Languages: eng Pagination: 560-8 Citation Subset: IM |
Affiliation:
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Department of Psychology, Southern Methodist University, 6424 Hilltop Lane, Dallas, TX 75205, United States. ameuret@smu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Gas Monitoring, Transcutaneous Breathing Exercises* Carbon Dioxide / metabolism* Child Disability Evaluation Feedback* Female Humans Hyperventilation / diagnosis, epidemiology Male Middle Aged Panic Disorder / epidemiology, metabolism*, therapy* Tidal Volume / physiology* Waiting Lists |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH056094-04/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
| Comments/Corrections | |
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