| Feedback control of milk secretion from milk. | |
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MedLine Citation:
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PMID: 10887504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular storage allows biologically-active substances in milk to influence mammary function. Among these factors is one which regulates the rate of milk secretion acutely according to frequency or completeness of milk removal in each mammary gland. The active factor in goat's milk has been identified by screening milk constituents for their ability to inhibit milk constituent secretion in tissue and cell culture bioassays, and found to be a novel milk protein. The proteins identified by bioassy in vitro, also inhibited milk secretion in lactating goats in a reversible, concentration-dependent manner. This protein, termed FIL (feedback inhibitor of lactation), acts by reversible blockade of constitutive secretion in the mammary epithelial cell. As the inhibitor is synthesized in the same epithelial cells, feedback inhibition is, therefore, an autocrine mechanism. FIL's unusual mechanism of action also influences other aspects of mammary function. Acute disruption of mammary membrane trafficking is associated with downregulation of prolactin receptors and followed by a decrease in epithelial cell differentiation. Thus, in addition to acutely-regulating milk secretion, FIL may induce the adaptation in mammary cell differentiation which acts in vivo to sustain the secretory response to a sustained change in milk removal. In the long term, matching of milk output to demand is achieved by a change in mammary cell number. This developmental response is also local in nature. Whether it too is due to autocrine modulation by FIL of mechanisms influencing cell proliferation or survival, or elicited by another milk-borne factor, remains to be determined. |
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Authors:
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M Peaker; C J Wilde |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of mammary gland biology and neoplasia Volume: 1 ISSN: 1083-3021 ISO Abbreviation: J Mammary Gland Biol Neoplasia Publication Date: 1996 Jul |
Date Detail:
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Created Date: 2000-07-24 Completed Date: 2000-07-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9601804 Medline TA: J Mammary Gland Biol Neoplasia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 307-15 Citation Subset: IM |
Affiliation:
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Hannah Research Institute, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast / physiology* Breast Feeding* Feedback Female Humans Lactation / physiology* Mammary Glands, Animal / physiology* Milk Milk, Human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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