Document Detail

Feedback control of glomerular filtration rate in isolated, blood-perfused dog kidneys.
MedLine Citation:
PMID:  910917     Owner:  NLM     Status:  MEDLINE    
Micropuncture studies were done in isolated, blood-perfused dog kidneys to investigate the intrarenal nature of tubuloglomerular feedback regulation of nephron filtration rate. Collections were made at early proximal tubular sites during alterations in flow through the loop of Henle to elicit the feedback response. Renal blood flow in the 10 isolated kidneys averaged 4 ml/ min-g kidney after an initial vasoconstriction. Filtration rate was 0.52 +/- 0.12 ml/min-g kidney for the period 90-120 min, but progressively fell after 120 min, as did fractional sodium reabsorption and PAH extraction. The feedback regulation of nephron filtration rate was demonstrated during the first 3 hrs of perfusion even with subnormal renal function. The feedback response expressed as the percent reduction of early proximal flow rate when loop of Henle flow was elevated from 0 to 45 nl/min was 41.3 +/- 4.5 (for the first 90 min), 35.3 +/- 7.5 (90-120 min), 24.3 +/- 6.8 (120-150 min), and 26.6 +/- 7.7% (150-180 min). After 180 min, the feedback response was no longer demonstrated. These results show that feedback-induced changes in nephron filtration rate are achieved in the absence of nervous system influences.
J Schnermann; N Stowe; S Yarimizu; M Magnsusson; G Tingwald
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  233     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F217-24     Citation Subset:  IM    
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MeSH Terms
Glomerular Filtration Rate*
Kidney / blood supply,  physiology*
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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