Document Detail

Feedback control of enflurane delivery in dogs--inspired compared to end-tidal control.
MedLine Citation:
PMID:  6410936     Owner:  NLM     Status:  MEDLINE    
A technique was studied for the rapid induction of anesthesia in a closed rebreathing circuit using feedback control of end-tidal enflurane concentration. This technique was compared to anesthetic induction using a constant inspired concentration. In one group of seven dogs, end-tidal enflurane concentration was maintained at 2.0%. Electronic feedback control automatically decreased the inspired concentration from a maximum of 3.7% to 2.1% during a 4-hr period. In the second group of seven dogs, the inspired enflurane concentration was 2.0% throughout the study. There was no statistically significant difference between the two groups with regard to enflurane uptake, heart rate, blood pressure, or cardiac output. Enflurane uptake was higher in the first group only during the first 6 min after induction. The induction technique that used feedback control to automatically adjust the inspired enflurane concentration appeared to have no adverse cardiovascular effects beyond those present during an induction using a constant inspired concentration.
D R Westenskow; W S Jordan; J K Hayes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  62     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  836-40     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation / instrumentation,  methods*
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Enflurane / administration & dosage*,  analysis
Heart Rate / drug effects
Nitrous Oxide
Oxygen / blood
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 13838-16-9/Enflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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