Document Detail

Feed thickener for newborn infants with gastro-oesophageal reflux.
MedLine Citation:
PMID:  12137682     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gastro-oesophageal reflux (GOR) is common in newborn infants. A common first line management is the use of feed thickeners.
OBJECTIVES: In newborn infants with GOR, to evaluate the use of feed thickeners in reducing signs and symptoms of GOR, acid episodes on pH monitoring and histological evidence of oesophagitis.
SEARCH STRATEGY: We searched MEDLINE from 1966 to December 2001, the Cochrane Controlled Trials Register, The Cochrane Library, Issue 1, 2002. CINAHL from 1982 to December 2001, and conference and symposia proceedings published in Pediatric Research 1990 to 1994. We also searched conference proceedings for the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN) and the North American Society for Pediatric Gastroenterology and Nutrition (NASPGAN) from 1994 to December 2001. We did not restrict the searches to the English language.
SELECTION CRITERIA: All randomised controlled trials that examine the effects of thickening formulas on treating gastro-oesophageal reflux in neonates. The eligible studies were to compare thickened feeds to no intervention (unthickened feeds).
DATA COLLECTION AND ANALYSIS: Two independent reviewers identified potential studies from the literature search. Quality was independently assessed by two independent reviewers.
MAIN RESULTS: No studies fulfilled the requirements for inclusion in the systematic review.
REVIEWER'S CONCLUSIONS: There is no evidence from randomised controlled trials to support or refute the efficacy of feed thickeners in newborn infants with GOR. Given the absence of evidence, we cannot recommend using thickening agents for management of GOR in newborn infants.
R C Huang; D A Forbes; M W Davies
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-24     Completed Date:  2002-09-24     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD003211     Citation Subset:  IM    
Gastroenterology, Princess Margaret Hospital, Perth, WA, Australia, Roberts Road, GPO D184, Perth, Western Australia, Australia.
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MeSH Terms
Food Additives / therapeutic use*
Gastroesophageal Reflux / therapy*
Infant, Newborn
Reg. No./Substance:
0/Food Additives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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