| Feed thickener for newborn infants with gastro-oesophageal reflux. | |
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MedLine Citation:
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PMID: 12137682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gastro-oesophageal reflux (GOR) is common in newborn infants. A common first line management is the use of feed thickeners. OBJECTIVES: In newborn infants with GOR, to evaluate the use of feed thickeners in reducing signs and symptoms of GOR, acid episodes on pH monitoring and histological evidence of oesophagitis. SEARCH STRATEGY: We searched MEDLINE from 1966 to December 2001, the Cochrane Controlled Trials Register, The Cochrane Library, Issue 1, 2002. CINAHL from 1982 to December 2001, and conference and symposia proceedings published in Pediatric Research 1990 to 1994. We also searched conference proceedings for the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN) and the North American Society for Pediatric Gastroenterology and Nutrition (NASPGAN) from 1994 to December 2001. We did not restrict the searches to the English language. SELECTION CRITERIA: All randomised controlled trials that examine the effects of thickening formulas on treating gastro-oesophageal reflux in neonates. The eligible studies were to compare thickened feeds to no intervention (unthickened feeds). DATA COLLECTION AND ANALYSIS: Two independent reviewers identified potential studies from the literature search. Quality was independently assessed by two independent reviewers. MAIN RESULTS: No studies fulfilled the requirements for inclusion in the systematic review. REVIEWER'S CONCLUSIONS: There is no evidence from randomised controlled trials to support or refute the efficacy of feed thickeners in newborn infants with GOR. Given the absence of evidence, we cannot recommend using thickening agents for management of GOR in newborn infants. |
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Authors:
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R C Huang; D A Forbes; M W Davies |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cochrane database of systematic reviews (Online) Volume: - ISSN: 1469-493X ISO Abbreviation: Cochrane Database Syst Rev Publication Date: 2002 |
Date Detail:
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Created Date: 2002-07-24 Completed Date: 2002-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100909747 Medline TA: Cochrane Database Syst Rev Country: England |
Other Details:
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Languages: eng Pagination: CD003211 Citation Subset: IM |
Affiliation:
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Gastroenterology, Princess Margaret Hospital, Perth, WA, Australia, Roberts Road, GPO D184, Perth, Western Australia, Australia. rae_chi@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Food Additives
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therapeutic use* Gastroesophageal Reflux / therapy* Humans Infant, Newborn |
| Chemical | |
Reg. No./Substance:
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0/Food Additives |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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