Document Detail

Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring.
MedLine Citation:
PMID:  23327414     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females.
STUDY DESIGN: From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring.
RESULTS: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin.
CONCLUSION: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
Sangmi Lee; Kyung A Lee; Gyu Yeon Choi; Mina Desai; Sun Hwa Lee; Myung-Geol Pang; Inho Jo; Young Ju Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-11
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  26     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2014-01-10     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  908-14     Citation Subset:  IM    
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MeSH Terms
Adiponectin / blood*
Animals, Newborn
Caloric Restriction*
Feeding Behavior / physiology
Lactation / physiology*
Leptin / blood*
Lipids / blood*
Prenatal Exposure Delayed Effects / blood*,  metabolism
Rats, Sprague-Dawley
Sex Characteristics
Grant Support
Reg. No./Substance:
0/Adiponectin; 0/Leptin; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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