Document Detail

Feed-forward loops and diamond motifs lead to tunable transmission of information in the frequency domain.
MedLine Citation:
PMID:  23005791     Owner:  NLM     Status:  Publisher    
Using a Gaussian model, we study the transmission of time-varying biochemical signals through feed-forward motifs and diamond motifs. To this end, we compute the frequency dependence of the gain, the noise, as well as their ratio, the gain-to-noise ratio, which measures how reliably a network transmits signals at different frequencies. We find that both coherent and incoherent feed-forward motifs can either act as low-pass or high-pass filters for information: The frequency dependence of the gain-to-noise ratio increases or decreases with increasing frequency, respectively. Our analysis of diamond motifs reveals that cooperative activation of the output component can increase the gain-to-noise ratio. This means that from the perspective of information transmission, it can be beneficial to split the input signal in two and recombine the two propagated signals at the output. Cooperative activation can be implemented via the formation of homo- or heteromultimers that then bind and activate the output component or via the binding of individual molecules of the intermediate species to the output component.
W H de Ronde; F Tostevin; P R Ten Wolde
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Physical review. E, Statistical, nonlinear, and soft matter physics     Volume:  86     ISSN:  1550-2376     ISO Abbreviation:  Phys Rev E Stat Nonlin Soft Matter Phys     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136452     Medline TA:  Phys Rev E Stat Nonlin Soft Matter Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  021913     Citation Subset:  -    
FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, Netherlands.
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