Document Detail


Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners.
MedLine Citation:
PMID:  16024538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B #100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option.
Authors:
L M Mabeck; M S Jensen; G Toft; M Thulstrup; M Andersson; T K Jensen; A Giwercman; J Olsen; J P Bonde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-07-15
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2006-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2909-15     Citation Subset:  IM    
Affiliation:
Department of Occupational Medicine, University Hospital of Aarhus, Aarhus Sygehus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Area Under Curve
Biological Markers
Female
Follicle Stimulating Hormone / metabolism
Humans
Inhibins / blood*
Male
Odds Ratio
Pregnancy
Pregnancy Outcome
Prospective Studies
ROC Curve
Reproductive History
Reproductive Medicine / methods*
Semen / metabolism
Sensitivity and Specificity
Spermatozoa / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/inhibin B; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone

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