| Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners. | |
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MedLine Citation:
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PMID: 16024538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B #100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option. |
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Authors:
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L M Mabeck; M S Jensen; G Toft; M Thulstrup; M Andersson; T K Jensen; A Giwercman; J Olsen; J P Bonde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-07-15 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 20 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-26 Completed Date: 2006-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2909-15 Citation Subset: IM |
Affiliation:
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Department of Occupational Medicine, University Hospital of Aarhus, Aarhus Sygehus, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Biological Markers Female Follicle Stimulating Hormone / metabolism Humans Inhibins / blood* Male Odds Ratio Pregnancy Pregnancy Outcome Prospective Studies ROC Curve Reproductive History Reproductive Medicine / methods* Semen / metabolism Sensitivity and Specificity Spermatozoa / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/inhibin B; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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