Document Detail


Fecal pancreatic elastase in infants under 2 years of age.
MedLine Citation:
PMID:  18957344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES AND METHODS: Fecal pancreatic elastase determination is of routine use in infant population presenting with a neonatal diagnosis of cystic fibrosis and in those with poor weight gain and growth, in order to precociously detect pancreatic insufficiency. However, there are few data regarding the value of one spot measure of elastase to assess pancreatic status in this population. This retrospective study reports the follow-up of fecal elastase measurement in 236 infants during the 2 first years of life. RESULTS: Fecal elastase was over 200 microg/g (i.e. normal cut-off) in a first sample in 122 patients (51.7% of patients) and below 200 microg/g in the remaining 114 patients. An alteration of elastase concentration was then observed in 18/122 infants (14.8%), leading to the diagnosis of pancreatic insufficiency at the end of the follow-up. In contrast, a normalization of fecal elastase was observed in 52 (45.6%) infants presenting with a first measurement below normal cut-off. CONCLUSION: This study shows that special attention should be given to the analysis of fecal elastase concentrations in infants as a precocious diagnosis of pancreatic insufficiency is crucial for the early introduction of a pancreatic enzyme replacement therapy which will prevent further consequence of malabsorption. One spot measure does not totally exclude pancreatic insufficiency in this population and a further control measurement of fecal elastase may be necessary.
Authors:
N A Benahmed; D Manene; L Barbot; N Kapel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annales de biologie clinique     Volume:  66     ISSN:  0003-3898     ISO Abbreviation:  Ann. Biol. Clin. (Paris)     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984690R     Medline TA:  Ann Biol Clin (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  IM    
Affiliation:
Laboratoire de coprologie fonctionnelle, APHP, Groupe hospitalier Pitié-Salpêtrière, Paris.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Exocrine Pancreatic Insufficiency / diagnosis*
Feces / enzymology*
Follow-Up Studies
Humans
Immunoenzyme Techniques
Infant
Infant, Newborn
Pancreatic Elastase / analysis*
Retrospective Studies
Time Factors
Chemical
Reg. No./Substance:
EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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