| Fecal calprotectin in very low birth weight infants. | |
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MedLine Citation:
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PMID: 17414135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To measure concentrations of fecal calprotectin (f-calprotectin) in infants with very low birth weight (VLBW; <1500 g) longitudinally and to describe changes in f-calprotectin in infants who develop severe abdominal disease. PATIENTS AND METHODS: The study included 59 VLBW infants. Seven patients (disease group) developed severe abdominal disease defined as necrotizing enterocolitis (NEC) or a condition leading to laparotomy. The remainder (n = 52) were considered reference infants and had a mean (+/-SD) gestational age of 27.2 +/- 2.6 weeks and a birth weight of 939 +/- 273 g. F-calprotectin was analyzed in meconium and weekly during postnatal weeks 1 to 8. In disease cases, more frequent samples were analyzed around the time of abdominal disease diagnosis. RESULTS: In reference infants the median (range) f-calprotectin level in meconium was 332 (12-9386) microg/g and correlated negatively to Apgar score. F-calprotectin in postmeconium samples was 253 (9-1867) microg/g and correlated positively to delivery by cesarean section, postnatal age, and volume of enteral feeds, and negatively to treatment with antibiotics and corticosteroids. In reference infants no postmeconium sample had f-calprotectin levels >2000 microg/g. In disease cases f-calprotectin was increased to >2000 microg/g in 3 cases of NEC and 1 case of covered perforation with microscopic bowel inflammation. In 1 case of NEC without microscopic bowel inflammation and 2 cases of focal intestinal perforation, f-calprotectin levels never exceeded 2000 microg/g. CONCLUSIONS: F-calprotectin concentrations in VLBW infants are similar to previously reported levels in healthy term and moderately preterm infants. An f-calprotectin level >2000 microg/g is a useful but not an early marker of NEC and other severe intestinal inflammatory conditions in VLBW infants. |
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Authors:
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Stina Josefsson; Susan K Bunn; Magnus Domellöf |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 44 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 407-13 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, Paediatrics, Umeå University Hospital, Umeå, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Enterocolitis, Necrotizing / diagnosis Feces / chemistry* Female Gastrointestinal Diseases / diagnosis* Humans Infant, Newborn Infant, Very Low Birth Weight* Leukocyte L1 Antigen Complex / analysis* Male Meconium / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Leukocyte L1 Antigen Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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