Document Detail

Fecal bile acids and neutral sterols in rats with spontaneous colon cancer.
MedLine Citation:
PMID:  3082773     Owner:  NLM     Status:  MEDLINE    
Fecal bile acids and neutral sterols of spontaneous colon cancer-bearing Wistar-Furth strain rats were examined and compared with those of control rats of the same strain by gas chromatography and gas chromatography-mass spectrometry. The amount of total fecal bile acids and the percentage of fecal lithocholic acid were almost similar in both groups, but the percentage of fecal deoxycholic acid was significantly higher in the colon cancer group than in the controls. The amount of total fecal neutral sterols and the percentage of fecal coprostanol were also markedly higher in the colon cancer group than in the controls. The percentage of cholesterol and the amount of beta-sitosterol were, however, almost similar in the two groups. These results indicate that fecal deoxycholic acid and fecal coprostanol are notably higher in rats with colon cancer than in controls.
E Hayashi; Y Amuro; T Endo; H Yamamoto; M Miyamoto; S Kishimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  37     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-20     Completed Date:  1986-05-20     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  629-32     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / analysis*
Cholestanol / analysis
Cholesterol / metabolism
Colonic Neoplasms / analysis*,  etiology
Feces / analysis*
Rats, Inbred WF
Sitosterols / analysis
Sterols / analysis*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Sitosterols; 0/Sterols; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 80-97-7/Cholestanol

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