| Fecal flora reconstitution for recurrent Clostridium difficile infection: results and methodology. | |
| | |
MedLine Citation:
|
PMID: 20485184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
GOALS: Recurrent Clostridium difficile infection (RCDI) is an increasingly common clinical problem without ideal treatment options. Our aim was to evaluate our results using Fecal Flora Reconstitution (FFR), and promulgate our methodology to the GI community to foster its more widespread use in appropriate candidates. BACKGROUND: FFR, sometimes termed "fecal transplantion" has been shown in numerous reports to be an effective treatment of RCDI, however, most of these studies have small sample sizes and few focus specifically on the methodology used in colonoscopic preparation and delivery of donated stool. STUDY: Nineteen patients with confirmed multiply recurrent CDI were treated by infusing donor stool through a colonoscope. RESULTS: Out of 19 patients, 18 initially responded to treatment with a single FFR treatment, 1 patient responded after a second FFR infusion. All 19 patients maintained prolonged cured status followed until submission, ranging from 6 months to 5 years. Three patients were presumed reinfected after remaining symptom free for a period spanning from 6 months to 4 years. These patients tested positive for C. difficile after prescription of additional antibiotics for unrelated infections. CONCLUSIONS: Fecal Flora Reconstitution is an effective, viable, and simple method of treatment for the difficult to treat patients with RCDI who fail standard therapy. |
| | |
Authors:
|
Faith Rohlke; Christina M Surawicz; Neil Stollman |
Related Documents
:
|
18518754 - Brain abscess: analysis of results in a series of 51 patients with a combined surgical ... 15926634 - Chronic osteomyelitis: results obtained by an integrated team approach to management. 2039204 - Comparison of different antibiotic regimens for therapy of 32 cases of q fever endocard... 16391904 - Transrectal ultrasound-guided prostate biopsy: is antibiotic prophylaxis necessary? 12153814 - Functional and anatomic results after two types of endoscopic endonasal dacryocystorhin... 20689204 - Voriconazole-refractory fungal infection of phacoemulsification tunnel. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-20 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 567-70 Citation Subset: IM |
Affiliation:
|
Northern California Gastroenterology Consultants, Oakland, CA 94609, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Clostridium difficile / isolation & purification* Enterocolitis, Pseudomembranous / microbiology, therapy* Feces / microbiology* Female Follow-Up Studies Humans Male Middle Aged Recurrence Retrospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gastric variceal bleeding uncovering a rare association of CREST syndrome, primary biliary cirrhosis...
Next Document: Does ablative therapy for Barrett esophagus affect the depth of subsequent esophageal biopsy as comp...