Document Detail

February 2002: 29-year-old woman with a skull mass for 2 months.
MedLine Citation:
PMID:  12146808     Owner:  NLM     Status:  MEDLINE    
A 29-year-old woman had a 2-month history of an enlarging lesion over her left frontal bone following minor trauma. CT scan showed an osteolytic lesion with an overlying soft tissue mass, thought to be an unhealed skull fracture with pseudomeningocele. Left frontal craniotomy revealed a soft tissue mass, which was resected. Histologic examination revealed multinucleated giant cells mixed with Langerhan's cells that showed the characteristic "coffee bean nuclei." Eosinophils were scant. Immunostaining for CD1a and S100 revealed strong positive staining primarily in the Langerhans' cells while giant cells and inflammatory cells were negative. Immunostaining for CD68, in contrast, stained the osteoclast-like giant cells and macrophages. Electron microscopy confirmed the presence Birbeck granules. The final diagnosis was Langerhans' cell histiocytosis (histiocytosis X) of the skull.
Kar-Ming Fung; Jason M Schwalb; Howard A Riina; Jasvir S Kurana; Justina M Mindaxy; M Sean Grady; Ehud Lavi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  12     ISSN:  1015-6305     ISO Abbreviation:  Brain Pathol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-30     Completed Date:  2003-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  393-4, 397     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA.
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MeSH Terms
Craniocerebral Trauma / complications*
Frontal Bone / injuries*,  surgery*
Histiocytosis, Langerhans-Cell / etiology*,  pathology,  surgery
Skull Fractures / pathology*,  surgery*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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