Document Detail

Febrile ulceronecrotic Mucha-Habermann's disease managed with methylprednisolone semipulse and subsequent methotrexate therapies.
MedLine Citation:
PMID:  14639403     Owner:  NLM     Status:  MEDLINE    
Febrile ulceronecrotic Mucha-Habermann's disease is an unusual severe form of pityriasis lichenoides et varioliformis acuta characterized by abrupt onset of ulceronecrotic eruption associated with a high fever and systemic symptoms. To our knowledge, 19 cases of this disease have been reported in the literature, and 4 of them were fatal. We report the case of a 12-year-old boy with this disorder who had abdominal pain, hypoproteinemia, and anemia. Although these associated symptoms are considered life-threatening factors according to reported cases, our patient was successfully treated with methylprednisolone semipulse and subsequent methotrexate therapies. From a review of the literature and the present case, we propose that when patients have these systemic symptoms, therapeutic choices include methotrexate, high-dose corticosteroids, and 4,4-diamino-diphenyl-sulfone, which may depress early development of this disease.
Natsuho Ito; Akihiro Ohshima; Hideo Hashizume; Masahiro Takigawa; Yoshiki Tokura
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  49     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-01-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1142-8     Citation Subset:  IM    
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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MeSH Terms
Methotrexate / administration & dosage*
Methylprednisolone / administration & dosage*
Pityriasis Lichenoides / drug therapy*,  pathology
Pulse Therapy, Drug
Reg. No./Substance:
59-05-2/Methotrexate; 83-43-2/Methylprednisolone

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