Document Detail

Febrile reaction associated with urokinase.
MedLine Citation:
PMID:  8159597     Owner:  NLM     Status:  MEDLINE    
Urokinase is an endogenously produced human proteolytic enzyme used to treat many thrombotic disorders. A 54-year-old man with recurrent myocardial infarction experienced fever during intracoronary urokinase infusion into a saphenous vein graft; the fever resolved after discontinuation of the infusion. After excluding all other possible etiologies of fever, urokinase was determined to be the cause. Several studies indicated that this reaction may be associated with urokinase infusion, but it is actually recognized by few individuals. This is the first published case report of the adverse event to our knowledge.
M H Shibley; G D Clifton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  14     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-05-16     Completed Date:  1994-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  IM    
Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky Medical Center, Lexington.
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MeSH Terms
Fever / chemically induced*
Infusions, Intravenous
Middle Aged
Myocardial Infarction / drug therapy
Urokinase-Type Plasminogen Activator / administration & dosage,  adverse effects*
Reg. No./Substance:
EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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