Document Detail


Features and parameters of drug-eluting stent deployment discoverable by intravascular ultrasound.
MedLine Citation:
PMID:  17950829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The only routinely available tool for assessing many features of stent implantation, intravascular ultrasound (IVUS) has become indispensable in trials of drug-eluting stents (DESs) and is currently the best way to identify or exclude causes of DES failure. Although IVUS resolution is not sufficient for determining reendothelialization, serial (postprocedure and follow-up) IVUS can measure intimal hyperplasia (IH), assess acute and late incomplete stent apposition, detect the presence and persistence of edge dissections, assess vascular responses such as remodeling, study edge effects, compare overlapping with nonoverlapping segments, and look for causes of restenosis and thrombosis. Percentage IH volume is one IVUS measure of efficacy that has been routinely assessed and compared in studies of DESs; IH volume and external elastic membrane, luminal, and stent cross-sectional area are others. This review details and evaluates IVUS findings in the important clinical trials conducted with the first-generation DESs: a sirolimus-eluting stent, a polymeric paclitaxel-eluting stent, and a nonpolymeric paclitaxel-eluting stent. IVUS results apparent in DES failure (restenosis and thrombosis) are also examined.
Authors:
Gary S Mintz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  100     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26M-35M     Citation Subset:  AIM; IM    
Affiliation:
Cardiovascular Research Foundation, New York, New York 10022, USA. gsm18439@aol.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage*
Coronary Restenosis / ultrasonography*
Coronary Thrombosis* / etiology,  therapy
Drug-Eluting Stents / adverse effects*
Humans
Hyperplasia / ultrasonography
Sirolimus / administration & dosage*
Tunica Intima / pathology*
Ultrasonography, Interventional / methods*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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