Document Detail


Features and outcomes in utero and after birth of fetuses with myocardial disease.
MedLine Citation:
PMID:  20976307     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objectives. Ninety-one fetuses with dilated or hypertrophic cardiomyopathy (DCM, HCM) and myocarditis were studied. Results. Group 1 "DCM" included 19 fetuses: 13 with hydrops (FH) and 5 with associated extracardiac anomalies (ECAs) (15.8%). Group 2 "Myocarditis" included twelve fetuses, having 11 with FH. Group 3 "HCM" included sixty fetuses: 26 had associated ECAs, 17 had maternal diabetes, and 17 were "idiopathic"; however, in one case, a metabolic disorder was found postnatally, and 4 had familiarity for HCM. Outcomes. Ten cases opted for termination of pregnancy. Two cases with DCM and 1 with HCM were lost at follow-up. Out of the cases that continued pregnancy, with known follow-up, mortality was 68.75% in Group 1, 63.6% in Group 2, and 31.3% in Group 3 (the majority with severe ECAs). Surviving cases with DCM and myocarditis improved, 2 with HCM worsened, 6 remained stable, and 26 improved or normalized. Conclusions. Our data show more severe prognosis in DCM and myocarditis and forms with severe associated ECAs.
Authors:
Vlasta Fesslova; Maurizio Mongiovì; Salvatore Pipitone; Jelena Brankovic; Laura Villa
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Publication Detail:
Type:  Journal Article     Date:  2010-10-03
Journal Detail:
Title:  International journal of pediatrics     Volume:  2010     ISSN:  1687-9759     ISO Abbreviation:  Int J Pediatr     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517077     Medline TA:  Int J Pediatr     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  628451     Citation Subset:  -    
Affiliation:
Center of Fetal Cardiology, Policlinico San Donato IRCCS, Via Morandi 30, San Donato Milanese, 20097 Milan, Italy.
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