| Features of large cell transformation of indolent lymphomas as observed on sequential PET/CT. | |
| | |
MedLine Citation:
|
PMID: 21169873 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Detection of large cell transformation (LCT) has been reported with the increasing use of PET/computed tomography (CT) in patients with indolent lymphomas. However, there is little information on PET/CT characteristics, specifically, the distribution of lesion maximum standardized uptake value (SUVmax) within a patient, or SUVmax changes before and after LCT. Our objectives were to compare SUVmax values and distribution between nontransformed and LCT patients; to compare SUVmax of LCT and nontransformed lesions in patients with documented focal transformation; and to measure the SUVmax changes in patients before and after LCT. METHODS: Retrospective study of patients with LCT (n=29)compared with nontransformed (n=41), and comparison of LCT and nontransformed lesions within patients and over time. RESULTS: On average, the highest SUVmax was greater in LCT patients than in nontransformed patients. In addition, there was a wider range of SUVmax values in the LCT group compared with the nontransformed group (P<0.05). The median ratio of the SUVmax of 12 LCT to nontransformed biopsy-proven lesions in the same patient was 4.3, P value of less than 0.05 (range 2.6-15.5). In 10 of 12 patients it was greater than or equal to 3. No change in highest SUVmax and distribution was shown on serial PET in untreated nontransformed patients. CONCLUSION: LCT is often focal and is associated with higher SUVmax than nontransformed. The emergence of a focus with SUVmax three times or higher than others on asingle scan, or that has tripled or more in value on serial scans, should raise suspicion for LCT. |
| | |
Authors:
|
Maroun Karam; Paul J Feustel; Chido D Vera; Tipu Nazeer |
Related Documents
:
|
19162573 - How do we interpret an elevated carbohydrate antigen 19-9 level in asymptomatic subjects? 11332283 - Long-term follow up of multibacillary leprosy patients with high bi treated with who/md... 17509753 - Middelheim fabry study (mifas): a retrospective belgian study on the prevalence of fabr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nuclear medicine communications Volume: 32 ISSN: 1473-5628 ISO Abbreviation: Nucl Med Commun Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
|
Languages: eng Pagination: 177-85 Citation Subset: IM |
Affiliation:
|
aDepartments of Radiology bNeuropharmacology and Neuroscience cPathology, Albany Medical College, Albany, New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Literate humans sound out words during silent reading.
Next Document: Goji Berry Effects on Macular Characteristics and Plasma Antioxidant Levels.