Document Detail

Features of large cell transformation of indolent lymphomas as observed on sequential PET/CT.
MedLine Citation:
PMID:  21169873     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Detection of large cell transformation (LCT) has been reported with the increasing use of PET/computed tomography (CT) in patients with indolent lymphomas. However, there is little information on PET/CT characteristics, specifically, the distribution of lesion maximum standardized uptake value (SUVmax) within a patient, or SUVmax changes before and after LCT. Our objectives were to compare SUVmax values and distribution between nontransformed and LCT patients; to compare SUVmax of LCT and nontransformed lesions in patients with documented focal transformation; and to measure the SUVmax changes in patients before and after LCT.
METHODS: Retrospective study of patients with LCT (n=29)compared with nontransformed (n=41), and comparison of LCT and nontransformed lesions within patients and over time.
RESULTS: On average, the highest SUVmax was greater in LCT patients than in nontransformed patients. In addition, there was a wider range of SUVmax values in the LCT group compared with the nontransformed group (P<0.05). The median ratio of the SUVmax of 12 LCT to nontransformed biopsy-proven lesions in the same patient was 4.3, P value of less than 0.05 (range 2.6-15.5). In 10 of 12 patients it was greater than or equal to 3. No change in highest SUVmax and distribution was shown on serial PET in untreated nontransformed patients.
CONCLUSION: LCT is often focal and is associated with higher SUVmax than nontransformed. The emergence of a focus with SUVmax three times or higher than others on asingle scan, or that has tripled or more in value on serial scans, should raise suspicion for LCT.
Maroun Karam; Paul J Feustel; Chido D Vera; Tipu Nazeer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  32     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  IM    
aDepartments of Radiology bNeuropharmacology and Neuroscience cPathology, Albany Medical College, Albany, New York, USA.
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