Document Detail

Features of ST segment and T-wave in exercise-induced myocardial ischemia evaluated with multichannel magnetocardiography.
MedLine Citation:
PMID:  12108575     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Magnetocardiography (MCG) is a novel, non-contact mapping technique to record cardiac magnetic field. We evaluated MCG criteria for myocardial ischemia in stress testing. METHODS: Multichannel MCG over frontal chest was performed in 44 patients with coronary artery disease (CAD) and 26 healthy controls during supine bicycle exercise test. Of the 44 patients 16 had anterior, 15 posterior, and 13 inferior ischemia documented by coronary angiography and exercise thallium scintigraphy. ST amplitude, ST slope, T-wave amplitude, and ST-T integral were measured. The optimal sites for detecting the ischemia-induced changes on MCG were sought. The orientation of the magnetic field was also determined. RESULTS: The optimal sites for the decrease of ST slope, ST amplitude, T-wave amplitude, and ST-T integral were over the abdomen. The reciprocal increase of these parameters was found over the left parasternal area. The optimal sites were approximately the same for all patient groups. In single-vessel disease patients without previous myocardial infarction (MI), ST slope increase and ST elevation performed the best (area under the receiver operating characteristic curve 92% and 90%, respectively). In post-MI patients with triple-vessel disease the decrease of T-wave amplitude and ST slope performed the best (area under curve 91%, for both). The magnetic field orientation at ST segment performed equally well as the other ST parameters. In stepwise logistic regression analysis, by use of the presence of CAD as the dependent parameter, ST slope increase and ST peak gradient orientation entered the model. CONCLUSIONS: Various ST segment and T-wave parameters detect ischemia in MCG. ST amplitude performs especially well in non-MI patients with less severe CAD. In advanced CAD late development of T-wave amplitude might be more sensitive to ischemia than ST amplitude.
Helena Hänninen; Panu Takala; Petri Korhonen; Lasse Oikarinen; Markku Mäkijärvi; Jukka Nenonen; Toivo Katila; Lauri Toivonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of medicine     Volume:  34     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-10     Completed Date:  2002-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-9     Citation Subset:  IM    
Division of Cardiology, Helsinki University Central Hospital, Finland.
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MeSH Terms
Body Surface Potential Mapping / instrumentation,  methods*
Case-Control Studies
Coronary Artery Disease / diagnosis,  physiopathology*
Echocardiography, Stress* / methods
Exercise Test
Heart Conduction System / physiopathology*
Logistic Models
Middle Aged
Myocardial Ischemia / diagnosis,  physiopathology*
Research Design
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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