Document Detail

Feasibility and validity were demonstrated of an online case-control study using the prototype of recent-onset systemic lupus erythematosus.
MedLine Citation:
PMID:  18342488     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the feasibility and validity of the online case-control study design through the empirical deployment of a prototype study of recent-onset systemic lupus erythematosus (SLE).
STUDY DESIGN AND SETTING: We conducted an Internet-based case-control study of SLE during 2003-2005. The source population comprised Google users searching on medical key terms, solicited using sponsored links. Cases fulfilled a self-administered algorithm for SLE diagnosed within 5 years. A subset underwent confirmation by medical record review. Controls were matched to cases using a propensity score.
RESULTS: Four hundred and two cases and 693 control applicants finished the questionnaires, yielding 389 matched case-control pairs. Eighty-two percentage of the records documented a clinical diagnosis of SLE, and 61% documented >or=4 American College of Rheumatology criteria for SLE. Control applicants resembled Internet users, with the exceptions of comprising more women (86% vs. 52%) and fewer minority individuals (e.g., 5% vs. 9% for African-Americans). There was a broad representation of clinical manifestations. SLE was associated with miscarriage (odds ratio [OR]=3.0, 95% confidence interval [CI]=2.0-4.7), allergy to sulfonamides (OR=2.2, CI=1.5-3.2), hives (OR=1.9, CI=1.4-2.5), and shingles (OR=2.3, CI=1.4-3.7).
CONCLUSION: It is possible to perform case-control studies over the Internet using an internally valid design, obtain reliable information from participants, and confirm established associations.
Timothy McAlindon; Jun Wang; Margaret Formica; Ashley Kay; Hocine Tighiouart; Christine Chaisson; Jeremiah Fletcher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Validation Studies     Date:  2008-03-14
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  61     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-08-07     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
Division of Rheumatology, Tufts-New England Medical Center, 750 Washington Street, Box 406, Boston, MA 02111, USA.
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MeSH Terms
Abortion, Spontaneous
Case-Control Studies*
Control Groups
Drug Hypersensitivity / complications
Feasibility Studies
Hypersensitivity / complications
Lupus Erythematosus, Systemic / complications,  epidemiology*
Middle Aged
Patient Selection
Grant Support
Reg. No./Substance:

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