Document Detail


Feasibility of using magnetic resonance elastography to study the effect of aging on shear modulus of skeletal muscle.
MedLine Citation:
PMID:  19299834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A common complication associated with aging is the stiffening of skeletal muscles. The purpose of this study was to determine the ability of magnetic resonance elastography (MRE) to study this phenomenon in vivo. Twenty female subjects were included in the study with an age range of 50 to 70 years. Shear modulus was calculated for the tibialis anterior of each subject. There was not a significant relationship between age and shear modulus. However, three subjects had abnormally high values and were among the oldest subjects tested. There was a significant relationship between age and tissue stiffness homogeneity. More research is needed to determine whether the changes seen here are reflective of increased tissue cross-linking or related to reduced muscle quality. However, MRE shows promise as a tool to study aging-related muscle stiffness changes or to evaluate treatments to counteract these changes.
Authors:
Zachary J Domire; Matthew B McCullough; Qingshan Chen; Kai-Nan An
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of applied biomechanics     Volume:  25     ISSN:  1065-8483     ISO Abbreviation:  J Appl Biomech     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-04-16     Revised Date:  2014-05-28    
Medline Journal Info:
Nlm Unique ID:  9315240     Medline TA:  J Appl Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Elastic Modulus / physiology
Elasticity Imaging Techniques / methods*
Feasibility Studies
Female
Humans
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Middle Aged
Muscle, Skeletal / physiology*,  ultrasonography*
Shear Strength
Stress, Mechanical
Young Adult
Grant Support
ID/Acronym/Agency:
R01 EB 00812/EB/NIBIB NIH HHS; R01 EB000812/EB/NIBIB NIH HHS; T32 HD 07447/HD/NICHD NIH HHS
Comments/Corrections

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