Document Detail

Feasibility of testing three salivary stress biomarkers in relation to naturalistic traffic noise exposure.
MedLine Citation:
PMID:  19758843     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Stress dependent alterations of the salivary biomarkers alpha-amylase (sAA), salivary chromogranin A (sCgA) and salivary cortisol (sC) have been reported in numerous studies recently. The aim of this pilot study was to investigate the feasibility of testing sAA, sCgA and sC in relation to naturalistic traffic noise exposure in order to monitor a direct stress response in a laboratory setup. METHODS: A total of twenty study participants were exposed to binaurally recorded naturalistic traffic noise samples containing 75 dB (L(A,)eq) for 20 minutes via a loudspeaker system. Saliva was collected directly before and after defined exposure to naturalistic traffic noise. Determination of sAA was performed enzymatically on a Hitachi 912 laboratory analyzer, sCgA was determined by ELISA technique and sC was determined using a RIA assay. RESULTS AND CONCLUSIONS: There was a significant increase of sAA and sC concentrations after traffic noise exposure (p=0.045; p=0.01), whereas for sCgA this was not observed (p=0.48). Measuring of sAA and sC appear to be feasible to investigate direct stress effects in relation to naturalistic traffic noise exposure in a laboratory setup. Considering the small sample size of this pilot study, these observations need to be further proved in a larger explorative study.
Jasmin Wagner; Michael Cik; Egon Marth; Brigitte I Santner; Eugen Gallasch; Andreas Lackner; Reinhard B Raggam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-15
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  213     ISSN:  1618-131X     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  153-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier GmbH. All rights reserved.
Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Austria.
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MeSH Terms
Biological Markers / metabolism
Chromogranin A / metabolism*
Feasibility Studies
Hydrocortisone / metabolism*
Noise / adverse effects*
Pilot Projects
Saliva / enzymology*
Stress, Physiological*
Young Adult
alpha-Amylases / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Chromogranin A; 50-23-7/Hydrocortisone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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