| Feasibility study of exploring a T(1) -weighted dynamic contrast-enhanced MR approach for brain perfusion imaging. | |
| | |
MedLine Citation:
|
PMID: 22314848 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To investigate the feasibility of T(1) -weighted dynamic contrast-enhanced (DCE) MRI for the measurement of brain perfusion. MATERIALS AND METHODS: Dynamic imaging was performed on a 3.0 Tesla (T) MR scanner by using a rapid spoiled-GRE protocol. T(1) measurement with driven equilibrium single pulse observation of T(1) (DESPOT1) was used to convert the MR signal to tracer concentration. Cerebral perfusion maps were obtained by using an improved gamma-variate model in 10 subjects and compared with those with arterial spin label (ASL) approach. RESULTS: The cerebral blood volume (CBV) values were calculated as 4.74 ± 1.09 and 2.29 ± 0.58 mL/100 g in gray matter (GM) and whiter matter (WM), respectively. Mean transit time (MTT) values were 6.15 ± 0.59 s in GM and 6.96 ± 0.79 s in WM. The DCE values for GM/WM cerebral blood flow (CBF) were measured as 53.41 ± 9.23 / 25.78 ± 8.91 mL/100 g/min, versus ASL values of 49.05 ± 10.81 / 23.00 ± 5.89 mL/100 g/min for GW/WM. Bland-Altman plot revealed a small difference of CBF between two approaches (mean bias = 3.83 mL/100 g/min, SD = 11.29). There were 6 pairs of samples (5%, 6/120) beyond the 95% limits of agreement. The correlation plots showed that the slop of Y (CBF_(DCE) ) versus X intercept (CBF_(ASL) ) is 0.95 with the intercept of 4.53 mL/100 g/min (r = 0.74; P < 0.05). CONCLUSION: It is feasible to evaluate the cerebral perfusion by using T(1) -weighted DCE-MRI with the improved kinetic model. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Yudong Zhang; Jing Wang; Xiaoying Wang; Jue Zhang; Jing Fang; Xuexiang Jiang |
Related Documents
:
|
11027878 - Novelty indices: identifiers of potentially interesting time-courses in functional mri ... 6293748 - Imaging of brain tumors and other lesions utilizing tc-99m phosphates and tc-99m pertec... 21586948 - Optimum height from the roof of the choana for seeking the sphenoid ostium. 12846548 - Tc-99m depreotide spect demonstrates photon-deficiency in the thoracic vertebrae after ... 2440168 - Evaluation of prostate size: a comparison of ultrasound and magnetic resonance imaging. 19785998 - Catestatin attenuates the effects of intrathecal nicotine and isoproterenol. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Radiology, Peking University First Hospital, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autophagy and apoptosis interplay during follicular atresia in fish ovary: a morphological and immun...
Next Document: A turn-on fluorogenic probe for detection of MDMA from ecstasy tablets.