Document Detail

Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction.
MedLine Citation:
PMID:  17182126     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study examined feasibility and safety of granulocyte colony-stimulating factor (G-CSF) treatment for patients with acute myocardial infarction (AMI). METHODS: Forty patients with AMI related with the left anterior descending coronary artery, who underwent successful percutaneous coronary intervention (PCI), were randomized into G-CSF group (n=18) or Control group (n=22). G-CSF treatment was started within 24 h after PCI. 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) was performed at 4 days and 6 months after AMI. SPECT data was analyzed for LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF) and myocardial perfusion. RESULTS: LVEF at 6 months was significantly better than that at 4 days in G-CSF group (p=0.013), but not changed in Control group (p=0.245). Although no significant difference was observed for LVEDV between the two groups, LVESV tended to be decreased only in G-CSF group. In G-CSF group, defect score (DS) was significantly decreased from 4 days to 6 months after AMI. Restenosis rate at 6 months after AMI was not significantly different between the two groups. CONCLUSIONS: G-CSF treatment for patients with AMI was effective and did not have any clinical and angiographic adverse effects.
Hiroyuki Takano; Hiroshi Hasegawa; Yoichi Kuwabara; Takashi Nakayama; Koki Matsuno; Yoshiya Miyazaki; Masashi Yamamoto; Yoshihide Fujimoto; Hisayuki Okada; Shinji Okubo; Miwa Fujita; Satoshi Shindo; Yoshio Kobayashi; Nobuyuki Komiyama; Noboru Takekoshi; Kamon Imai; Toshiharu Himi; Iwao Ishibashi; Issei Komuro
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2006-12-19
Journal Detail:
Title:  International journal of cardiology     Volume:  122     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-08     Completed Date:  2007-12-13     Revised Date:  2009-06-02    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Combined Modality Therapy
Feasibility Studies
Granulocyte Colony-Stimulating Factor / therapeutic use*
Middle Aged
Myocardial Infarction / radiography,  radionuclide imaging,  therapy*
Prospective Studies
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor
Comment In:
Int J Cardiol. 2009 Jun 12;135(1):111-4; author reply 115-6   [PMID:  18440658 ]

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