| Feasibility, safety and efficacy of an early aerobic rehabilitation program for patients after minor ischemic stroke: A pilot randomized controlled trial. | |
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MedLine Citation:
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PMID: 21447908 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To examine the feasibility, safety and effectiveness of an early aerobic rehabilitation program for patients after minor ischemic stroke. Design: Randomized control trial. Methods: Twenty-eight patients, 1-3 weeks post minor ischemic stroke (modified Rankin scale; mRS ⩽ 2), were randomly assigned to intervention or control groups. Measures were taken at weeks 1 and 6. All participants were instructed in home practice to achieve strength and flexibility, and were asked to continue their normal community routine. Intervention group participants performed a supervised exercise training program twice a week for 6 weeks. Exercise capacity was evaluated by the 6-minute walk distance test (6MWD), and the modified Bruce treadmill test. Results: Eight subjects out of 14 participated in all 12 training sessions, one at less than 50% of the sessions, while five reached the highest stage of the program. No adverse events were noted during the intervention period. In the intention to treat analysis a significant improvement over time was seen for the functional parameters only. No interaction (group*time) was found. According to the per protocol analysis a significant interaction effect was found; only the intervention group participants showed a significant clinical change in the 6MWD test (412 ± 178 meters to 472 ± 196 meters, vs the control group 459 ± 116 meters to 484 ± 122 meters, p< 0.01). Conclusions: An early supervised aerobic training after minor ischemic stroke is feasible and well tolerated and, in a per-protocol analysis, was associated with improved walking endurance. Further studies with a larger sample size are needed to assess the effect of such a program on functional abilities, prevention of risk factors, and recurrent stroke. |
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Authors:
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Adi Toledano-Zarhi; David Tanne; Eli Carmeli; Michal Katz-Leurer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: NeuroRehabilitation Volume: 28 ISSN: 1878-6448 ISO Abbreviation: NeuroRehabilitation Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9113791 Medline TA: NeuroRehabilitation Country: Netherlands |
Other Details:
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Languages: eng Pagination: 85-90 Citation Subset: IM |
Affiliation:
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Physical Therapy Department, School of Health Professions, Tel Aviv University, Ramat Aviv, Israel Stroke Center, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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