| Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation. | |
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MedLine Citation:
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PMID: 20685246 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Five patients with aggressive acute leukemias who had relapsed after cord blood transplantation were treated with cord blood derived cytokine-induced killer (CIK) cells. These were obtained by ex vivo expansion, using as starting material the washouts of the cord blood units, left over at the end of the transplant. We did not observe any acute or delayed adverse event, and observed 1 partial response in 1 patient concomitantly with the development of acute grade III graft-versus-host disease (GVHD). These observations show the relatively low toxicity of cord blood-derived CIK cells and, more importantly, the feasibility of this immunotherapy program for patients who could not otherwise benefit from donor lymphocyte infusions. |
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Authors:
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Martino Introna; Alice Pievani; Gianmaria Borleri; Chiara Capelli; Alessandra Algarotti; Caterina Micò; Anna Grassi; Elena Oldani; Josée Golay; Alessandro Rambaldi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: 16 ISSN: 1523-6536 ISO Abbreviation: Biol. Blood Marrow Transplant. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 1603-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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USC Hematology, Ospedali Riuniti Bergamo, Italy. mintrona@ospedaliriuniti.bergamo.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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