Document Detail


Feasibility of myxomatous mitral valve repair using direct leaflet and chordal radiofrequency ablation.
MedLine Citation:
PMID:  18973508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Minimally invasive repair of mitral valve prolapse (MVP) causing severe mitral regurgitation (MR) should reduce MR and have chronic durability. Our ex vivo, acute in vivo, and chronic in vivo studies suggest that direct application of radiofrequency ablation (RFA) to mitral leaflets and chordae can effect these repair goals to decrease MR.
METHODS: A total of seven canines were studied to assess the effects of RFA on mitral valve structure and function. RFA was applied ex vivo (n = 1), acutely in vivo using a right lateral thoracotomy and cardiopulmonary bypass (n = 3), and chronically in vivo using percutaneous access to the heart (n = 3). RFA was applied to the mitral valve and its associated chordae. Mitral valve structure and function (in vivo preparations) were then assessed.
RESULTS: Ex vivo application of RFA resulted in qualitative reduction in mitral leaflet surface area and chordal length. Acute in vivo application of RFA to canines found to have MVP causing severe MR demonstrated a 43.7-60.7% statistically significant (P = 0.039) reduction in postablation MR. Chronic, in vivo, percutaneous application of RFA was found to be feasible and the engendered alterations durable.
CONCLUSION: These data suggest that myxomatous mitral valve repair using radiofrequency energy delivered via catheter is feasible.
Authors:
Jeffrey L Williams; Yoshiya Toyoda; Takeyoshi Ota; Dmitry Gutkin; William Katz; Marco Zenati; David Schwartzman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-10-21
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  21     ISSN:  1540-8183     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-05-25     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-54     Citation Subset:  IM    
Affiliation:
Good Samaritan Health System, Lebanon Cardiology Associates, Lebanon, Pennsylvania 17042, USA. lcaep@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheter Ablation / methods*
Disease Models, Animal
Dogs
Echocardiography
Mitral Valve Insufficiency / etiology,  therapy*,  ultrasonography
Mitral Valve Prolapse / physiopathology,  therapy*,  ultrasonography
Pennsylvania
Treatment Outcome
Grant Support
ID/Acronym/Agency:
L30 HL085922-01/HL/NHLBI NIH HHS
Comments/Corrections

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