| Feasibility of multiple-mouse dynamic contrast-enhanced MRI. | |
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MedLine Citation:
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PMID: 17763350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced (DCE-) MRI is often used to evaluate the response to experimental antiangiogenic therapies in small animal models of cancer. Unfortunately, DCE-MRI studies often require a substantial investment of both time and money to achieve the desired level of statistical significance. Multiple-mouse MRI has previously been used to improve imaging efficiency, but its feasibility for DCE-MRI has not been investigated. The purpose of this work was to determine if multiple-mouse DCE-MRI is feasible when using gadolinium-based contrast agents with a low molecular weight. A population of tumor-bearing mice was scanned using two four-element arrays and a single-coil configuration on a 4.7T, 40 cm bore Bruker Biospec MRI scanner. Pharmacokinetic parameters were calculated and compared to determine if a significant difference between methodologies existed. With both four-animal imaging configurations, animal throughput accelerations of just less than three were achieved and quantitative data were not significantly different than from single-animal acquisitions. |
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Authors:
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Marc S Ramirez; Dustin K Ragan; Vikas Kundra; James A Bankson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 58 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-05 Completed Date: 2007-12-07 Revised Date: 2010-07-08 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 610-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Imaging Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Contrast Media* / pharmacokinetics Disease Models, Animal Equipment Design Feasibility Studies Fibrosarcoma / pathology Gadolinium DTPA / diagnostic use, pharmacokinetics Image Enhancement / instrumentation, methods* Injections, Subcutaneous Magnetic Resonance Imaging / instrumentation, methods* Mice Mice, Nude Neoplasm Transplantation Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA-110181/CA/NCI NIH HHS; CA-16672/CA/NCI NIH HHS; R21 CA110181-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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