Document Detail


Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance.
MedLine Citation:
PMID:  18212521     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations.
METHODS: Arteriovenous malformation (AVM) and intracranial aneurysm patients undergoing noninvasive management were treated with minocycline or doxycycline (200 mg/day) up to 2 years in a prospective open-label safety pilot trial. The primary outcome was to compare dose-limiting intolerance, defined as treatment-related dose reduction or withdrawal between the agents.
RESULTS: Twenty-six patients with AVMs (n = 12) or aneurysms (n = 14) were recruited. Adverse event rates were similar to other reported trials of these agents; 4 of 13 (31%) minocycline and 3 of 13 (23%) doxycycline patients had dose-limiting intolerance (hazard ratio = 3.1, 95% CI = 0.52-18.11, log rank p = 0.70).
CONCLUSIONS: It is feasible to propose a long-term trial to assess the potential benefit of tetracycline therapy to decrease hemorrhagic risk in brain vascular malformations.
Authors:
Tim Frenzel; Chanhung Z Lee; Helen Kim; Nancy J Quinnine; Tomoki Hashimoto; Michael T Lawton; B Joseph Guglielmo; Charles E McCulloch; William L Young
Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-01-23
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  25     ISSN:  1421-9786     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-10     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anti-Bacterial Agents / administration & dosage*,  adverse effects*
Dose-Response Relationship, Drug
Doxycycline / administration & dosage*,  adverse effects*
Feasibility Studies
Follow-Up Studies
Humans
Intracranial Aneurysm / drug therapy
Intracranial Arteriovenous Malformations / drug therapy
Middle Aged
Minocycline / administration & dosage*,  adverse effects*
Pilot Projects
Prospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
NS34949/NS/NINDS NIH HHS; R01 NS034949/NS/NINDS NIH HHS; R01 NS034949-12/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; FYY3R43WGO/Minocycline; N12000U13O/Doxycycline
Comments/Corrections

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