| Feasibility of intrafraction whole-body motion tracking for total marrow irradiation. | |
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MedLine Citation:
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PMID: 21639586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With image-guided tomotherapy, highly targeted total marrow irradiation (TMI) has become a feasible alternative to conventional total body irradiation. The uncertainties in patient localization and intrafraction motion of the whole body during hour-long TMI treatment may pose a risk to the safety and accuracy of targeted radiation treatment. The feasibility of near-infrared markers and optical tracking system (OTS) is accessed along with a megavoltage scanning system of tomotherapy. Three near-infrared markers placed on the face of a rando phantom are used to evaluate the capability of OTS in measuring changes in the markers' positions as the rando is moved in the translational direction. The OTS is also employed to determine breathing motion related changes in the position of 16 markers placed on the chest surface of human volunteers. The maximum uncertainty in locating marker position with the OTS is 1.5 mm. In the case of normal and deep breathing motion, the maximum marker position change is observed in anterior-posterior direction with the respective values of 4 and 12 mm. The OTS is able to measure surface changes due to breathing motion. The OTS may be optimized to monitor whole body motion during TMI to increase the accuracy of treatment delivery and reduce the radiation dose to the lungs. |
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Authors:
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Manju Sharma; Troy Dos Santos; Nikolaos P Papanikolopoulos; Susanta Kumar Hui |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of biomedical optics Volume: 16 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-06 Completed Date: 2012-02-28 Revised Date: 2012-05-22 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 058002 Citation Subset: IM |
Affiliation:
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Department of Therapeutic Radiology-Radiation Oncology,University of Minnesota Medical School, MMC 494-420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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radiation effects* Dose Fractionation* Equipment Design Equipment Failure Analysis Feasibility Studies Humans Radiotherapy, Conformal / instrumentation* Whole Body Imaging / instrumentation* |
| Grant Support | |
ID/Acronym/Agency:
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P30 CA77398/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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