| Feasibility of integrated CT-liver perfusion in routine FDG-PET/CT. | |
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MedLine Citation:
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PMID: 19593563 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To integrate CT-perfusion into a routine, clinical contrast-enhanced (ce) PET/CT protocol for the evaluation of liver metastases and to compare functional CT and PET parameters. MATERIALS AND METHODS: Forty-six consecutive patients (mean age: 60 (34-82) years; 20 f, 26 m) with known liver lesions (colorectal metastases (n = 34), primary liver cancer (n = 4), breast cancer (n = 3), anal cancer, gastric cancer, esophageal cancer, GIST, duodenal cancer (all: n = 1) who were referred for staging or therapy follow-up by [18F]-Fluoro-2-deoxy-D-glucose-positron-emission-tomography/computed-tomography imaging (FDG-PET/CT) were included. After acquisition of a low-dose PET/CT, a split-injection (70-90 mL) ce-CT-protocol, including a 35-s CT-perfusion scan of the liver and a diagnostic ce-CT of the thorax and/or abdomen (70 s delay, iv-contrast volume: 90 mL, 4 mL/s) was performed. CT-perfusion parameters (BF, BV, MTT,) and semi-quantitative PET-parameters (SUVmax, SUVmean, TLG, PETvol) were analyzed and compared. RESULTS: CT-perfusion data could be obtained in all but one patient with shallow breathing. In all patients, diagnostic ce-PET/CT quality was adequate without the use of additional contrast media. Significant correlations (P < 0.05) were found for each of BF, BV, MTT, and SUVmax, further, BF and MTT correlated with TLG. Several other correlations were seen for other perfusion and PET-parameters. CONCLUSION: Combined CT-perfusion/PET/CT-protocol without the use of additional contrast media is feasible and can be easily integrated in clinical routine. Perfusion parameters and PET-parameters are only partly correlating and therefore have to be investigated further at fixed time points during the course of disease and therapy. |
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Authors:
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Patrick Veit-Haibach; Valerie Treyer; Klaus Strobel; Jan D Soyka; Lars Husmann; Niklaus G Schaefer; Alois Tschopp; Thomas F Hany |
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Publication Detail:
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Type: Journal Article Date: 2009-07-11 |
Journal Detail:
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Title: Abdominal imaging Volume: 35 ISSN: 1432-0509 ISO Abbreviation: Abdom Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303672 Medline TA: Abdom Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 528-36 Citation Subset: IM |
Affiliation:
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Department of Medical Radiology, Division of Nuclear Medicine, University Hospital Zuerich, Raemistrasse 100, 8091, Zuerich, Switzerland. patrick.veit@gmx.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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