| Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats. | |
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MedLine Citation:
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PMID: 20461252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo(13)C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized (15)N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized (15)N labeled choline in live animals. |
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Authors:
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Cristina Cudalbu; Arnaud Comment; Fiodar Kurdzesau; Ruud B van Heeswijk; Kai Uffmann; Sami Jannin; Vladimir Denisov; Deniz Kirik; Rolf Gruetter |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-12 |
Journal Detail:
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Title: Physical chemistry chemical physics : PCCP Volume: 12 ISSN: 1463-9084 ISO Abbreviation: Phys Chem Chem Phys Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888160 Medline TA: Phys Chem Chem Phys Country: England |
Other Details:
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Languages: eng Pagination: 5818-23 Citation Subset: IM |
Affiliation:
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Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-IPMC-LIFMET, Office F1 602, Station 6, CH-1015 Lausanne, Switzerland. cristina.cudalbu@epfl.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Choline / chemistry* Isotope Labeling Magnetic Resonance Imaging / methods* Male Nitrogen Isotopes / chemistry Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Isotopes; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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