| Feasibility of five days of consecutive leukocytapheresis for the treatment of ulcerative colitis: a preliminary study. | |
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MedLine Citation:
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PMID: 19379165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukocytapheresis (LCAP) has been applied for the treatment of steroid refractory ulcerative colitis (UC). A standard protocol employs one or two sessions of LCAP per week. Our aim was to determine whether five consecutive LCAP sessions can be performed safely and effectively for UC patients. Six patients with moderately active UC were enrolled. The patients received five days of consecutive LCAP in which the processing volume of blood was limited to 1500 mL per session. The hemoglobin levels in each patient gradually decreased, and the platelet count by the fifth session reached half of the value before the first session. The clinical activity index in two patients improved daily, and they went into remission with an improvement in the colonic endoscopic appearance after one week. This preliminary study showed that five consecutive LCAP sessions are safe and feasible for active UC patients. The therapeutic efficacy and suitable patients for this treatment protocol should be confirmed by further studies. |
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Authors:
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Tomoyuki Tsujikawa; Akira Andoh; Atsuhiro Ogaẃa; Ayano Sonoda; Yuhki Yagi; Kazuori Hata; Masaya Sasaki; Yasaharu Saito; Yoshihide Fujiyama |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 13 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-04-21 Completed Date: 2009-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, Japan. tujikawa@belle.shiga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Colitis, Ulcerative / blood, therapy* Colonoscopy Female Glucocorticoids / therapeutic use Hemoglobins / metabolism Humans Leukapheresis / methods* Male Pilot Projects Platelet Count Remission Induction / methods Severity of Illness Index Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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