Document Detail


Feasibility of five days of consecutive leukocytapheresis for the treatment of ulcerative colitis: a preliminary study.
MedLine Citation:
PMID:  19379165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukocytapheresis (LCAP) has been applied for the treatment of steroid refractory ulcerative colitis (UC). A standard protocol employs one or two sessions of LCAP per week. Our aim was to determine whether five consecutive LCAP sessions can be performed safely and effectively for UC patients. Six patients with moderately active UC were enrolled. The patients received five days of consecutive LCAP in which the processing volume of blood was limited to 1500 mL per session. The hemoglobin levels in each patient gradually decreased, and the platelet count by the fifth session reached half of the value before the first session. The clinical activity index in two patients improved daily, and they went into remission with an improvement in the colonic endoscopic appearance after one week. This preliminary study showed that five consecutive LCAP sessions are safe and feasible for active UC patients. The therapeutic efficacy and suitable patients for this treatment protocol should be confirmed by further studies.
Authors:
Tomoyuki Tsujikawa; Akira Andoh; Atsuhiro Ogaẃa; Ayano Sonoda; Yuhki Yagi; Kazuori Hata; Masaya Sasaki; Yasaharu Saito; Yoshihide Fujiyama
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  13     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, Japan. tujikawa@belle.shiga-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Colitis, Ulcerative / blood,  therapy*
Colonoscopy
Female
Glucocorticoids / therapeutic use
Hemoglobins / metabolism
Humans
Leukapheresis / methods*
Male
Pilot Projects
Platelet Count
Remission Induction / methods
Severity of Illness Index
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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