| Feasibility and drug delivery efficiency of a new balloon angioplasty catheter capable of performing simultaneous local drug delivery. | |
| | |
MedLine Citation:
|
PMID: 8173708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Local drug delivery at angioplasty treatment sites may improve acute and long-term results after angioplasty. A new dual-purpose balloon angioplasty catheter containing intramural channels and exterior pores ('channeled balloon') was designed to allow local drug delivery at low pressure without jet streams during simultaneous balloon angioplasty. METHODS: Acute feasibility studies were performed in normal ex-vivo and in-vivo arteries (three canine arteries and three rabbits with normal iliac arteries), in which 2 ml of marker agents were locally infused at 2 atm during simultaneous angioplasty at 6 atm with the channeled balloon. Histology, radioactive counting, and autoradiography were performed to determine the intramural localization of the delivered markers. The in-vitro efficiency of acute local drug delivery was estimated in seven normal canine arteries by infusing 3H-heparin and radioactive counting. RESULTS: Histology revealed the presence of markers in the inner third of the media in all ex-vivo samples, and markers in all in-vivo iliac arteries except for one, whereas control segments had no intramural staining. Autoradiography documented transmural radioactive granules. Radioactive counts were 40- to 263-fold higher in those locally treated with the radioactive marker agent. Efficiency of the acute local delivery was estimated by dividing the actual counts by the expected counts; it ranged from 24 to 48%. CONCLUSION: This study demonstrates that the channeled balloon is capable of delivering drugs locally at low pressure in adequate concentrations during simultaneous high-pressure balloon angioplasty in normal arteries. |
| | |
Authors:
|
M K Hong; S C Wong; A Farb; M D Mehlman; R Virmani; J J Barry; M B Leon |
Related Documents
:
|
1473918 - Deformation characteristics of a bioabsorbable intravascular stent. 20102958 - Retinal vascular patterns after operative repair of aortic isthmic coarctation. 3591308 - Renovascular hypertension in a child with rett's syndrome. 20703478 - Intraoperative sac pressure measurement during endovascular abdominal aortic aneurysm r... 19143688 - Triggering of systolic arterial pressure alarms using statistics-based versus threshold... 2912568 - Variability and reproducibility of quantitative left ventricular angiography. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Coronary artery disease Volume: 4 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1993 Nov |
Date Detail:
|
Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1023-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine (Cardiology Division), Washington Hospital Center, Washington, DC 20010. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary
/
instrumentation* Animals Dogs Drug Delivery Systems / instrumentation* Heart Catheterization / instrumentation* Pressure Rabbits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Baseline characteristics and therapeutic goals in the New Approaches to Coronary Intervention (NACI)...
Next Document: Serum immunoglobulin E and sudden cardiac arrest during myocardial infarction.