Document Detail

Feasibility of capillary velocity assessment by statistical means using dual-beam spectral-domain Optical Coherence Tomography: a preliminary study.
MedLine Citation:
PMID:  23303589     Owner:  NLM     Status:  Publisher    
The assessment of vascular dynamics has been shown to yield both qualitative and quantitative metrics and thus play a pivotal role in the diagnosis and prognosis of various diseases, which may manifest as microcirculatory irregularities. Optical Coherence Tomography (OCT) is an established imaging modality which utilises the principle of optical interferometry to distinguish between spatial changes in refractive index and thus formulate a multi-dimensional representation of a specimen in vivo. Nonetheless, difficulties remain in obtaining accurate data (morphological and/or transient) in an environment which is subject to such large biological variability. In an effort to address the issue of angular dependence as with Doppler based analysis, a dual-beam Spectral-domain OCT system for quasi-simultaneous specimen scanning is described. A statistical based method of phase correlation is outlined which is capable of quantifying velocity values in addition to the ability to discern bidirectionality, without the necessity of angular computation. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).
Susan M Daly; Christophe Silien; Martin J Leahy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Journal of biophotonics     Volume:  -     ISSN:  1864-0648     ISO Abbreviation:  J Biophotonics     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318567     Medline TA:  J Biophotonics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Dept. Physics and Energy, University of Limerick, Ireland.
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