| Feasibility of biventricular pacing in patients with recent myocardial infarction: impact on ventricular remodeling. | |
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MedLine Citation:
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PMID: 17268205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that biventricular pacing after a myocardial infarction with reduced ejection fraction can attenuate left ventricular (LV) remodeling, the authors studied 18 patients (myocardial infarction within 30-45 days, ejection fraction <or=30%, narrow QRS) randomized to biventricular therapy (biventricular therapy + defibrillator) (biventricular group) or implantable cardioverter-defibrillator alone (control group). At 1, 6, and 12 months, there were no differences in functional or clinical parameters (New York Heart Association, quality of life, 6-minute walk). Twelve-month LV volume remained stable in the biventricular group, but increased in the control group (median LV end-diastolic volume increase, 6.5 mL in biventricular vs 35 mL in control; P=.03; median LV end-diastolic volume decrease, 5.5 mL in biventricular vs 30.5-mL increase in control; P=.11). Biventricular therapy also prevented an increase in sphericity index at 12 months (median, -2% in biventricular vs 37% in control; P=.06). Delivery of biventricular therapy early after myocardial infarction appears safe and feasible and may attenuate subsequent LV dilation. |
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Authors:
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Eugene S Chung; Santosh G Menon; Raul Weiss; Edward J Schloss; Theodore Chow; Dean J Kereiakes; Wojciech Mazur; Rodney W Salo; Elizabeth Galle; Joseph M Pastore |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 13 ISSN: 1527-5299 ISO Abbreviation: Congest Heart Fail Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-02-01 Completed Date: 2007-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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The Christ Hospital, Ohio Heart and Vascular Center, and the Lindner Clinical Trial Center, Cincinnati, OH 45219, USA. chunge@ohioheart.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Pacing, Artificial / methods* Feasibility Studies Female Follow-Up Studies Heart Rate / physiology Humans Male Middle Aged Myocardial Contraction / physiology Myocardial Infarction / physiopathology, therapy* Retrospective Studies Treatment Outcome Ventricular Function, Left / physiology* Ventricular Remodeling* |
| Comments/Corrections | |
Comment In:
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Congest Heart Fail. 2007 Jan-Feb;13(1):53-4
[PMID:
17268211
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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