Document Detail

Feasibility of biventricular pacing in patients with recent myocardial infarction: impact on ventricular remodeling.
MedLine Citation:
PMID:  17268205     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that biventricular pacing after a myocardial infarction with reduced ejection fraction can attenuate left ventricular (LV) remodeling, the authors studied 18 patients (myocardial infarction within 30-45 days, ejection fraction <or=30%, narrow QRS) randomized to biventricular therapy (biventricular therapy + defibrillator) (biventricular group) or implantable cardioverter-defibrillator alone (control group). At 1, 6, and 12 months, there were no differences in functional or clinical parameters (New York Heart Association, quality of life, 6-minute walk). Twelve-month LV volume remained stable in the biventricular group, but increased in the control group (median LV end-diastolic volume increase, 6.5 mL in biventricular vs 35 mL in control; P=.03; median LV end-diastolic volume decrease, 5.5 mL in biventricular vs 30.5-mL increase in control; P=.11). Biventricular therapy also prevented an increase in sphericity index at 12 months (median, -2% in biventricular vs 37% in control; P=.06). Delivery of biventricular therapy early after myocardial infarction appears safe and feasible and may attenuate subsequent LV dilation.
Eugene S Chung; Santosh G Menon; Raul Weiss; Edward J Schloss; Theodore Chow; Dean J Kereiakes; Wojciech Mazur; Rodney W Salo; Elizabeth Galle; Joseph M Pastore
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  13     ISSN:  1527-5299     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
The Christ Hospital, Ohio Heart and Vascular Center, and the Lindner Clinical Trial Center, Cincinnati, OH 45219, USA.
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MeSH Terms
Cardiac Pacing, Artificial / methods*
Feasibility Studies
Follow-Up Studies
Heart Rate / physiology
Middle Aged
Myocardial Contraction / physiology
Myocardial Infarction / physiopathology,  therapy*
Retrospective Studies
Treatment Outcome
Ventricular Function, Left / physiology*
Ventricular Remodeling*
Comment In:
Congest Heart Fail. 2007 Jan-Feb;13(1):53-4   [PMID:  17268211 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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