Document Detail


Feasibility of automated warning in subjects with localization-related epilepsies.
MedLine Citation:
PMID:  21030315     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Automated seizure detection ushers the prospect for issuance of warning, but to benefit from it, patients must be responsive when warnings are issued. By use of a complex reaction time test triggered by a seizure detection algorithm, the latency to impairment of responsiveness was measured during seizure versus interictal conditions in 14 patients undergoing surgical evaluation with intracranial electrodes. Mean latency to impairment of responsiveness from electrographic onset was 27.1, 42.8, or 56.1seconds depending on the stringency of the defining criterion. Mean, SD, and distributions of compliance and percentage of correct responses did not significantly differ between seizure and interictal tests. If reproduced in studies performed under more realistic conditions, the latency to impairment of responsiveness justifies the development of a warning device to allow patients to perform activities precluded by seizures and decrease the risk of injury. If endowed with automated therapy delivery, said device would advance epilepsy management cost-effectively.
Authors:
Ivan Osorio; M Frei
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Publication Detail:
Type:  Journal Article     Date:  2010-10-27
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  19     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
University of Kansas Medical Center, Kansas City, KS, USA; Flint Hills Scientific, L.L.C., Lawrence, KS, USA.
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