Document Detail

A feasibility study of quantitative molecular characterization of musculoskeletal lesions by proton MR spectroscopy at 3 T.
MedLine Citation:
PMID:  20566784     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study is to establish the feasibility and potential value of measuring the concentration of choline-containing compounds by proton MR spectroscopy (MRS) in musculoskeletal lesions at 3 T.
SUBJECTS AND METHODS: Thirty-three subjects with 34 musculoskeletal lesions (four histologically proven malignant, 13 histologically proven benign or proven benign by follow-up analysis, and 17 posttreatment fibrosis with documented stability for 6-36 months) underwent single-voxel 3-T MRS studies. In each case, both water-suppressed and water-unsuppressed scans were obtained. The quality of the scans was recorded as excellent, adequate, or nondiagnostic, and the choline concentration was measured using water as the internal reference. The choline concentrations of benign and malignant lesions were compared using the Mann-Whitney test.
RESULTS: Spectral quality was excellent in 26 cases, adequate in four cases, and nondiagnostic in four cases. For malignant lesions (three sarcomas), the choline concentrations were 1.5, 2.9, and 3.8 mmol/kg, respectively. For five benign lesions (two neurofibromas, two schwannomas, and one enchondroma), the choline concentrations were 0.11, 0.28, 0.13, 0.8, and 1.2 mmol/kg, respectively. For seven benign lesions (two hematomas, two bone cysts, one lipoma, one giant cell tumor, and one pigmented villonodular synovitis), the spectra showed negligible choline content. For three posttreatment fibrosis cases, the choline concentration range was 0.2-0.4 mmol/kg. For the remaining 12 posttreatment fibrosis cases, the spectra showed negligible choline content. Average choline concentrations were different for malignant and benign lesions (2.7 vs 0.5 mmol/kg; p = 0.01).
CONCLUSION: The measurement of choline concentration within musculoskeletal lesions by MRS is feasible using an internal water-referencing method at 3 T and has potential for characterizing lesions for malignancy.
Laura M Fayad; Xin Wang; Nouha Salibi; Peter B Barker; Michael A Jacobs; Antonio J Machado; Kristy L Weber; David A Bluemke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  195     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-07-15     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W69-75     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Markers / analysis
Choline / analysis*
Contrast Media
Feasibility Studies
Image Interpretation, Computer-Assisted
Magnetic Resonance Spectroscopy / methods*
Middle Aged
Muscle Neoplasms / diagnosis*,  pathology
Musculoskeletal Diseases / diagnosis*,  pathology
Predictive Value of Tests
Statistics, Nonparametric
Grant Support
1R01CA100184/CA/NCI NIH HHS; P50CA103175/CA/NCI NIH HHS; R01 CA100184/CA/NCI NIH HHS; R01 CA100184-01A2/CA/NCI NIH HHS; R01 CA100184-02/CA/NCI NIH HHS; R01 CA100184-03/CA/NCI NIH HHS; ZIA CL090019-01/CL/CLC NIH HHS; ZIA EB000072-01/EB/NIBIB NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Contrast Media; 0/Protons; N91BDP6H0X/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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