| Feasibility of Measuring Human Pancreatic Perfusion In Vivo Using Imaging Techniques. | |
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MedLine Citation:
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PMID: 21562446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: The objective of this study was to demonstrate the feasibility of pancreatic perfusion computed tomography (CT) and review pancreatic perfusion measurements by various imaging modalities. METHODS:: Dynamic CT data from 8 patients (4 men; mean age, 64.8 [SD, 12.1] years; range, 40-80 years) with normal pancreas were analyzed using 2 analytical models: the maximum-slope and compartment-model methods. Literature search was also performed. RESULTS:: Although the perfusion value estimated by the maximum-slope method (88.1 [SD, 42.1] mL/min per 100 mL) was significantly smaller than that of the compartment-model method (127.0 [SD, 70.5]; P < 0.001), there was a linear correlation between them (r = 0.97, P < 0.001). In the literature review, 15 studies that reported the absolute values of normal pancreatic perfusion, by using perfusion CT, dynamic magnetic resonance imaging, hydrogen gas clearance method, and O-H2O-positron emission tomography were found. The reported mean values of normal pancreatic perfusion ranged from 38.4 to 356 mL/min per 100 mL, and there was a great deal of individual variation. CONCLUSIONS:: Perfusion CT may provide reliable perfusion measurements of the pancreas, and the normal value was estimated at around 100 mL/min per 100 mL with a great deal of individual variation. The maximum-slope method may provide a lower perfusion value compared with the compartment-model method. |
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Authors:
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Yoshito Tsushima; Masaya Miyazaki; Ayako Taketomi-Takahashi; Keigo Endo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-10 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Hospital, Gunma, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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