| Feasibility and Effectiveness of Early Initiation of Combination Antiretroviral Therapy in HIV-infected Infants in a Government Clinic of Kwazulu-Natal, South Africa. | |
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MedLine Citation:
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PMID: 21705764 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A recent randomized trial showed dramatic improvement in survival of HIV-infected infants receiving early combination antiretroviral therapy (cART). However, few data are available for resource-limited settings. Therefore we conducted a chart review of HIV-infected infants initiated on cART between 2005 and 2008. Of 129 treated infants, 94 completed 6 months, 62 completed 12 months, and 39 completed 18 months of cART. Median age at initiation of cART was 8.6 months (range 2.1-11.9) and 77.2% had advanced disease. Undetectable VL was found in 78.8% of children who reached 18 months of treatment. CD4% increased from a median of 15.4% at baseline to 33.1% at 18 months. Weight for age Z-score increased from a mean ± SD of -2.7 ± 1.97 to 0.02 ± 1.10 at 18 months. Findings show favourable response to cART in HIV-infected infants outside a research environment, despite initial advanced disease. Efforts should be made to initiate cART as early as possible. |
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Authors:
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Susan E Purchase; Dimitri J Van der Linden; Neil H McKerrow |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: - ISSN: 1465-3664 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Paediatrics, Pietermarizburg Metropolitan Hospitals Complex, Pietermaritzburg, 3200, South Africa. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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