| Feasibility of Doppler variance imaging for red blood cell aggregation characterization. | |
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MedLine Citation:
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PMID: 20059238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An abnormal level of red blood cell (RBC) aggregation is a clinical condition associated with many pathologies. Our purpose is to investigate the feasibility of spectral domain phase-resolved optical Doppler tomography incorporated with Doppler variance imaging to characterize RBC aggregation in flowing blood. Variance/standard deviation (SD) of the Doppler frequency spectrum of porcine blood flowing through a glass tube (diameter 300 microm) at 4.7 mms is measured. For nonaggregating RBCs with hematocrits of 20, 40, and 60%, the mean centerline SD values were 34.2+/-1.2, 47.8+/-1.0, and 47.2+/-0.5, respectively. After dextran 500 induction, the SD value decreased significantly to 29.9+/-0.7, 37.9+/-3.0, and 40.1+/-0.6 (P<0.01) in the aggregated blood, respectively. The results demonstrate that Doppler variance imaging using the SD value is capable of differentiating normal and aggregated blood. |
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Authors:
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Xiangqun Xu; Yeh-Chan Ahn; Zhongping Chen |
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Publication Detail:
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Type: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 14 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-30 Revised Date: 2011-05-30 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 060507 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Doppler Effect* Erythrocyte Aggregation* Erythrocytes / physiology* Hematocrit Swine Tomography, Optical / methods* |
| Grant Support | |
ID/Acronym/Agency:
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CA-91717/CA/NCI NIH HHS; EB-00293/EB/NIBIB NIH HHS; R01 CA091717-05/CA/NCI NIH HHS; R01 EB000293-08/EB/NIBIB NIH HHS; RR-01192/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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