Document Detail

Feasibility of CT-guided percutaneous needle biopsy in early diagnosis of BOOP.
MedLine Citation:
PMID:  18236106     Owner:  NLM     Status:  MEDLINE    
Bronchiolitis obliterans organizing pneumonia (BOOP) is a nonneoplastic, noninfectious lung disease with a diverse spectrum of imaging abnormalities and nonspecific symptoms diagnosed by open lung biopsy, transbronchial biopsy, and/or video-assisted thoracoscopy. The objective of this study was to retrospectively assess the role of percutaneous computed tomography (CT)-guided biopsy in early diagnosis of the disorder. Fourteen BOOP cases diagnosed by CT-guided biopsy were analyzed in terms of imaging abnormalities and complication rate. All had previously undergone a nondiagnostic procedure (bronchoscopy, transbronchial biopsy, bronchoalveolar lavage) to exclude infection or lung cancer. The most common imaging abnormalities in descending order were bilateral consolidations (5/14), unilateral tumor-like lesions (5/14), unilateral consolidations (3/14), and diffuse reticular pattern (1/14). Coexistent abnormalities (pleural effusions, nodules, ground-glass opacities) were observed in five patients. The complication rate was 4 of 14 (28.6%), including 2 cases of subclinical pneumothorax and 1 case of minor hemoptysis and local lung injury. None required intervention. We conclude that transthoracic CT-guided biopsy may be used in the diagnosis of BOOP in selected patients with mild complications. For the focal consolidation nodule/mass imaging pattern, CT-guided biopsy may prove to be a reasonable alternative to more invasive procedures.
Loukia S Poulou; Iris Tsangaridou; Petros Filippoussis; Nektaria Sidiropoulou; Sofia Apostolopoulou; Loukas Thanos
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Publication Detail:
Type:  Journal Article     Date:  2008-01-31
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  31     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-09-12     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1003-7     Citation Subset:  IM    
Department of Medical Imaging and Interventional Radiology, General Hospital of Chest Diseases Sotiria, Mesogeion Av. 152, Athens, 11527, Greece.
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MeSH Terms
Biopsy, Needle / methods*
Bronchoalveolar Lavage Fluid / cytology
Cohort Studies
Cryptogenic Organizing Pneumonia / diagnosis,  pathology*,  radiography*
Early Diagnosis
Feasibility Studies
Follow-Up Studies
Middle Aged
Radiography, Interventional / methods
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Tomography, X-Ray Computed / methods*

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